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Test Code:
VITD125OH

Order Name:
Vitamin D 1,25-Dihydroxy (MAYO Lab-USA) **

 
Useful For:

As a second-order test in the assessment of vitamin D status, especially in patients with renal disease

Investigation of some patients with clinical evidence of vitamin D deficiency (eg, vitamin D-dependent rickets due to hereditary deficiency of renal 1-alpha hydroxylase or end-organ resistance to 1,25-dihydroxyvitamin D)

Differential diagnosis of hypercalcemia

 
Methodology:
Extraction/Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
 
 
 
Test Code:
VITD125OH

Order Name:
Vitamin D 1,25-Dihydroxy (MAYO Lab-USA) **

 
Patient Preparation:
Fasting (4-hour preferred but not required)
 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 2 tubes
 
Specimen Testing Type:
Serum, minimum volume 1.5 mL per tube 
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Refrigerated, 2oC to 8oC (preferred) 7 days
Ambient 7 days
Frozen 28 days
 
 
 
Test Code:
VITD125OH

Order Name:
Vitamin D 1,25-Dihydroxy (MAYO Lab-USA) **

 
Method detail:
Extraction/Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
 
Schedule:
N/A **Sent out to MAYO, USA
 
Turnaround Time:
Received specimen to report within 14 days
 
Performing Location:
MAYO Laboratory
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
VITD125OH

Order Name:
Vitamin D 1,25-Dihydroxy (MAYO Lab-USA) **

 
 
Clinical Information:
Vitamin D is a generic designation for a group of fat-soluble, structurally similar sterols, which act as hormones. In the presence of renal disease or hypercalcemia, testing of 1,25-dihydroxy vitamin D (DHVD) might be needed to adequately assess vitamin D status. The 25-hydroxyvitamin D (25HDN) test (25HDN / 25-Hydroxyvitamin D2 and D3, Serum) in serum is otherwise the preferred initial test for assessing vitamin D status and most accurately reflects the body's vitamin D stores.

Advisory Information: The 25-hydroxyvitamin D test (25-Hydroxyvitamin D2 and D3, Serum) in serum the preferred initial test for assessing vitamin D status and most accurately reflects the body's vitamin D stores. In the presence of renal disease or hypercalcemia, testing of 1,25-dihydroxy vitamin D (DHVD) might be needed to adequately assess vitamin D status.
 
Reference Value:
Males:
<16 years: 24-86 pg/mL
> or =16 years: 18-64 pg/mL

Females:
<16 years: 24-86 pg/mL
> or =16 years: 18-78 pg/mL
 
Interpretation:
1,25-Dihydroxyvitamin D (DVHD) concentrations are low in chronic renal failure and hypoparathyroidism.

DVHD concentrations are high in sarcoidosis and other granulomatous diseases, some malignancies, primary hyperparathyroidism, and physiologic hyperparathyroidism.

DVHD concentrations are not a reliable indicator of vitamin D toxicity; normal (or even low) results may be seen in such cases.
 
Clinical Reference:
www.mayomedicallaboratories.com (Retrieved: 31 Jul 2020)