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Clear
 
Test Code:
090-31-2860-01

Order Name:
Vasoactive Intestinal Polypeptide (VIP) **

 
Useful For:
Detection of vasoactive intestinal polypeptide producing tumors in patients with chronic diarrheal diseases.
 
Methodology:
Radioimmunoassay (RIA)
 
 
 
Test Code:
090-31-2860-01

Order Name:
Vasoactive Intestinal Polypeptide (VIP) **

 
Patient Preparation:
  • Fasting (8 hours)
  • This test should not be requested on patients who have recently received radioactive material.
 
Collection Specimen Or Container:
Blood/ K3 EDTA (Lavender Top) 3 mL, 3 tubes
 
Specimen Testing Type:
Plasma EDTA, minimum volume 1 mL x 2 tube
Centrifuge and freeze immediately.
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Gross hemolysis Reject
Gross lipemia Reject
Gross icterus OK
 
Specimen Stabillity:
Specimen Type Temperature Time
Plasma EDTA Frozen  90 days
 
 
 
Test Code:
090-31-2860-01

Order Name:
Vasoactive Intestinal Polypeptide (VIP) **

 
Method detail:
Radioimmunoassay (RIA)
 
Schedule:
N/A **Sent out to MAYO, USA
 
Turnaround Time:
14 days
 
Performing Location:
MAYO Laboratory
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
090-31-2860-01

Order Name:
Vasoactive Intestinal Polypeptide (VIP) **

 
 
Clinical Information:

Vasoactive intestinal polypeptide (VIP) was originally isolated from porcine small intestine and was recognized by its potent vasodilator activity. This brain/gut hormone has widespread distribution and is present in neuronal cell bodies localized in the central nervous system, digestive, respiratory, and urogenital tracts, and exocrine, thyroid, and adrenal glands. VIP has a wide scope of biological actions. The main effects of VIP include relaxation of smooth muscle (bronchial and vascular dilation), stimulation of gastrointestinal water and electrolyte secretion, and release of pancreatic hormones.

VIP-producing tumors (VIPomas) are rare; most (90%) are located in the pancreas. Watery diarrhea, hypokalemia, and achlorhydria are key symptoms.

 
Reference Value:
<75 pg/mL
 
Interpretation:
Values above 75 pg/mL may indicate the presence of an enteropancreatic tumor causing hypersecretion of vasoactive intestinal polypeptide (VIP).
Values above 200 pg/mL are strongly suggestive of VIP-producing tumors (VIPoma).
VIPoma is unlikely with a 24-hour stool volume below 700 mL.

Cautions: This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. A recommended time period before collection cannot be made because it will depend on the isotope administered, the dose given and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive samples received in the laboratory will be held and assayed after the radioactivity has sufficiently decayed. This will result in a test delay.
 
Clinical Reference:
www.mayomedicallaboratories.com (Retrieved: 31 Jul 2020)