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Test Code:
TSH

Order Name:
TSH (Thyroid Stimulating Hormone)*

 
Useful For:
Screening for thyroid dysfunction and detecting mild (subclinical), as well as overt, primary hypo- or hyperthyroidism in ambulatory patients.

Monitoring patients on thyroid replacement therapy.

Confirmation of thyroid-stimulating hormone (TSH) suppression in thyroid cancer patients on thyroxine suppression therapy.

Prediction of thyrotropin-releasing hormone-stimulated TSH response.
 
Methodology:
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
AliasesName:
Thyroid Stimulating Hormone
TSH
 
 
 
Test Code:
TSH

Order Name:
TSH (Thyroid Stimulating Hormone)*

 
Collection Specimen Or Container:
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 1 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: 4+ reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serun (keep in original tube) Room temperature, 20oC to 28oC 24 hours
Serum Refrigerated, 2oC to 8oC 7 days
Frozen, -10oC 6 months
 
 
 
Test Code:
TSH

Order Name:
TSH (Thyroid Stimulating Hormone)*

 
Schedule:
Tested Daily (24 Hours)
 
Turnaround Time:
Specimen collected to reported within 2:00 Hours (120 Mins)
 
Performing Location:
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
TSH

Order Name:
TSH (Thyroid Stimulating Hormone)*

 
 
Clinical Information:
In primary hypothyroidism, thyroid-stimulating hormone (TSH) levels will be elevated. In primary hyperthyroidism, TSH levels will be low. The ability to quantitate circulating levels of TSH is important in evaluating thyroid function. It is especially useful in the differential diagnosis of primary (thyroid) from secondary (pituitary) and tertiary (hypothalamus) hypothyroidism. In primary hypothyroidism, TSH levels are significantly elevated, while in secondary and tertiary hypothyroidism, TSH levels are low or normal.

Elevated or low TSH in the context of normal free thyroxine is often referred to as subclinical hypo- or hyperthyroidism, respectively. Thyrotropin-releasing hormone (TRH) stimulation differentiates all types of hypothyroidism by observing the change in patient TSH levels in response to TRH. Typically, the TSH response to TRH stimulation is exaggerated in cases of primary hypothyroidism, absent in secondary hypothyroidism, and delayed in tertiary hypothyroidism. Most individuals with primary hyperthyroidism have TSH suppression and do not respond to TRH stimulation with an increase in TSH over their basal value.

Sick, hospitalized patients may have falsely low or transiently elevated TSH.
 
Clinical Reference:
  1. https://www.mayocliniclabs.com (Retrieved: Feb 2020)
  2. Manufacturer’s Reagent package insert Architect TSH, November 2015, Abbott Ireland Diagnostic Division, Lisnamuck, Longford Co., Ireland.