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Test Code (รหัสการทดสอบ):
090-10-1000

Order Name (ชื่อการทดสอบ):
Serum Free Light Chain

 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Turnaround Time (ระยะเวลารอผล):
Receive to Report within 1 day
 
Useful For (ประโยชน์การทดสอบ):
Monitoring patients with monoclonal light chain diseases but no M-spike on protein electrophoresis (Monoclonal Gammopathy)
 
Methodology (วิธีการทดสอบ):
Turbidimetric assay 
 
AliasesName (ชื่อเรียกอื่นๆ) :
Immunoglobulin Free Light Chains, Serum
FLC
Free Light Chain
 
 
 
Test Code (รหัสการทดสอบ):
090-10-1000

Order Name (ชื่อการทดสอบ):
Serum Free Light Chain

 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Serum, minimum volume 2 mL
 
Sub Mission Container (ภาชนะส่งตรวจ):
Plastic tube
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):

 
 
 
 
Test Code (รหัสการทดสอบ):
090-10-1000

Order Name (ชื่อการทดสอบ):
Serum Free Light Chain

 
Method detail (วิธีการทดสอบ):
Turbidimetric assay 
 
Turnaround Time (ระยะเวลารอผล):
Receive to Report within 1 day
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Hematology, Laboratory Department Tel. 17254
 
 
 
Test Code (รหัสการทดสอบ):
090-10-1000

Order Name (ชื่อการทดสอบ):
Serum Free Light Chain

 
 
Clinical Information (ข้อมูลทางคลินิก):
The monoclonal gammopathies include multiple myeloma (MM), light chain multiple myeloma (LCMM), Waldenstrom macroglobulinemia (WM), nonsecretory myeloma (NSMM), smoldering multiple myeloma (SMM), monoclonal gammopathy of undetermined significance (MGUS), primary systemic amyloidosis (AL), and light chain deposition disease (LCDD). Monoclonal proteins are typically detected by serum protein electrophoresis (SPEP) and immunofixation (IF). However, the monoclonal light chain diseases (LCMM, AL, LCDD) and NSMM often do not have serum monoclonal proteins in high enough concentration to be detected and quantitated by SPEP. A sensitive nephelometric assay specific for kappa free light chain (FLC) and lambda free light chain (FLC) that doesn't recognize light chains bound to Ig heavy chains has recently been described. This automated, nephelometric assay is reported to be more sensitive than IF for detection of monoclonal FLC. In some patients with NSMM, AL, or LCDD the FLC assay provides a positive identification of a monoclonal serum light chain when the serum IF is negative. In addition, the quantitation of FLC has been correlated with disease activity in patients with NSMM and AL.