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Test Code:
090-10-1000

Order Name:
Serum Free Light Chain

 
Useful For:
Monitoring patients with monoclonal light chain diseases but no M-spike on protein electrophoresis (Monoclonal Gammopathy)
 
Methodology:
Turbidimetric assay 
 
AliasesName:
Immunoglobulin Free Light Chains, Serum
FLC
Free Light Chain
 
 
 
Test Code:
090-10-1000

Order Name:
Serum Free Light Chain

 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 2 mL
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:

 
 
 
 
Test Code:
090-10-1000

Order Name:
Serum Free Light Chain

 
Method detail:
Turbidimetric assay 
 
Turnaround Time:
Received to Reported within 1 day
 
Performing Location:
Hematology, Laboratory Department Tel. 17254
 
 
 
Test Code:
090-10-1000

Order Name:
Serum Free Light Chain

 
 
Clinical Information:
The monoclonal gammopathies include multiple myeloma (MM), light chain multiple myeloma (LCMM), Waldenstrom macroglobulinemia (WM), nonsecretory myeloma (NSMM), smoldering multiple myeloma (SMM), monoclonal gammopathy of undetermined significance (MGUS), primary systemic amyloidosis (AL), and light chain deposition disease (LCDD). Monoclonal proteins are typically detected by serum protein electrophoresis (SPEP) and immunofixation (IF). However, the monoclonal light chain diseases (LCMM, AL, LCDD) and NSMM often do not have serum monoclonal proteins in high enough concentration to be detected and quantitated by SPEP. A sensitive nephelometric assay specific for kappa free light chain (FLC) and lambda free light chain (FLC) that doesn't recognize light chains bound to Ig heavy chains has recently been described. This automated, nephelometric assay is reported to be more sensitive than IF for detection of monoclonal FLC. In some patients with NSMM, AL, or LCDD the FLC assay provides a positive identification of a monoclonal serum light chain when the serum IF is negative. In addition, the quantitation of FLC has been correlated with disease activity in patients with NSMM and AL.