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Test Code:
090-70-8305-01

Order Name:
Saccharomyces cerevisiae Antibody (ASCA), IgA

 
Useful For:
Use to distinguish between ulcerative colitis and Crohn disease in patients having signs and symptoms of inflammatory bowel disease
 
Methodology:
Enzyme-linked Immunosorbent Assay (ELISA)
 
AliasesName:
ASCA (Anti-Saccharomyces cerevisiae Antibody) IgA
Crohn disease
Saccharomyces cerevisiae Ab
 
 
 
Test Code:
090-70-8305-01

Order Name:
Saccharomyces cerevisiae Antibody (ASCA), IgA

 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 0.5 mL
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Hemolysis: Mild OK; Gross reject
Lipemia: Mild OK; Gross reject
Icterus: Mild OK; Gross reject
Other: N/A
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Refrigerated, 2oC to 8oC 14 days
 
 
 
Test Code:
090-70-8305-01

Order Name:
Saccharomyces cerevisiae Antibody (ASCA), IgA

 
Method detail:
Enzyme-linked Immunosorbent Assay (ELISA)
 
Schedule:
Test daily, at 01:00 p.m.
 
Turnaround Time:
Received specimen to reported within 2 days.
 
Performing Location:
Molecular biology & Genetics, Laboratory Department Tel.14168
 
Specimen Retention Time:
7 days
 
 
 
Test Code:
090-70-8305-01

Order Name:
Saccharomyces cerevisiae Antibody (ASCA), IgA

 
 
Clinical Information:
In patient with Crohn's disease antibodies against microorganisms of the intestinal flora are found more frequently than in healthy individuals. This probably reflects the increased immunoreactivity of the compromised intestinum. Antibodies against Saccharomyces cerevisiae are frequently found in the serum of patients suffereing from Crohn's disease. They enable the diagnostic differentation of Crohn's disease and ulceration colitis. Antibodies against Saccharomyces cerevisiae enrich the serological diagnosis of chronic inflammatory bowel disease by a further parameter, in addition to autoantibodies against exocrine pancrease, intestinal goblet cells and granulocytes (pANCA).
 
Reference Value:
< 20 RU/mL
 
Interpretation:
Either antibodies against Saccharomyces cerevisiae IgA or IgG is found in the serum of 67% of patients with Crohn's disease. These antibodies are rarely observed in ulcerative colitis. Around 40% of patients with Crohn's disease have increased levels of both Saccharomyces cerevisiae Antibody IgA and IgG. A diagnosis should not be made based on a single test result. The clinical symptoms of the patient should always be taken into account along with the other serological results by the physician.
 
Clinical Reference:
Manufacturer’s reagent package insert, Anti-Saccharomyces cerevisiae ELISA (IgA) Test instruction, September 2011, EUROIMMUN, Lübeck, D-23560 Germany.