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Test Code:
SHBG

Order Name:
SHBG (Sex Hormone Binding Globulin)

 
Useful For:
  • Determination of sex hormone binding globulin (SHBG) in human serum.
  • Used as an aid in the diagnosis of androgen disorders.
 
Methodology:
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
AliasesName:
Sex Hormone Binding Globulin
SHBG 
 
 
 
Test Code:
SHBG

Order Name:
SHBG (Sex Hormone Binding Globulin)

 
Collection Specimen Or Container:
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 1 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: 4+ reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum (keep in original tube) Room temperature, 20oC to 28oC 8 hours
Serum Refrigerated, 2oC to 8oC 8 days
Frozen, -20oC 3 months
 
 
 
Test Code:
SHBG

Order Name:
SHBG (Sex Hormone Binding Globulin)

 
Method detail:
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
Schedule:
Tested Daily (24 Hours)
 
Turnaround Time:
Specimen collected to reported within 2:00 Hours (120 Mins)
 
Performing Location:
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
SHBG

Order Name:
SHBG (Sex Hormone Binding Globulin)

 
 
Clinical Information:
Sex hormone binding globulin (SHBG) is a glycoprotein of about 80-100 kDa; it has a high affinity for 17 beta-hydroxysteroid hormones such as testosterone and estradiol. SHBG concentration in plasma is regulated by, amongst other things, androgen/estrogen balance, thyroid hormones, insulin and dietary factors. It is the most important transport protein for estrogens and androgens in peripheral blood. SHBG concentration is a major factor regulating their distribution between the protein-bound and free states. Plasma SHBG concentrations are affected by a number of different diseases, high values being found in hyperthyroidism, hypogonadism, androgen insensitivity and hepatic cirrhosis in men. Low concentrations are found in myxoedema, hyperprolactinaemia and syndromes of excessive androgen activity. Measurement of SHBG is useful in the evaluation of mild disorders of androgen metabolism and enables identification of those women with hirsutism who are more likely to respond to estrogen therapy. The ratio of testosterone to SHBG is also known as the Free Androgen Index (FAI) or the Free Testosterone Index (FTI). This ratio correlates well
with both measured and calculated values of free testosterone and helps to discriminate subjects with excessive androgen activity from normal individuals.
 
Reference Value:
Sex Reference value Unit
Male 17.1 - 77.6 nmol/L
Female (Premenopausal) 34.3 - 147.7 nmol/L
Female (Postmenopausal) 26.4 - 118.0 nmol/L
 
Clinical Reference:
Manufacturer’s Reagent package insert Architect SHBG, February 2018, Abbott GmbH & Co. KG, Max-Planck-Ring 2, 65205 Wiesbaden, Germany.