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Test Code:
PS

Order Name:
Protein S

 
Useful For:
Evaluating patients with a history of venous thromboembolism.
 
Methodology:
Clotting assay
 
AliasesName:
Free Protein S Antigen
 
 
 
Test Code:
PS

Order Name:
Protein S

 
Collection Specimen Or Container:
Blood/ Sodium citrate tube (Sodium Citrate 3.2% anticoagulant, Blue top) 3 mL, 2 tubes
 
Specimen Testing Type:
Citrate plasma, minimum volume 0.5 mL
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Hemolysis: Hemoglobin >200 mg/dL
Lipemia: Triglyceride >1,500 mg/dL
Icterus: Bilirubin >25 mg/dL
Other: Clotted specimen will be rejected.
 
Specimen Stabillity:
Specimen Type Temperature Time
Whole blood, Sodium citrate Room temperature, 18oC to 25oC 4 hours
Plasma, Sodium citrate Room temperature, 18oC to 25oC 4 hours
Refrigerated, 2oC to 8oC 4 hours
Frozen, -20oC 2 weeks
Frozen, -70oC 1 year
 
 
 
Test Code:
PS

Order Name:
Protein S

 
Method detail:
Clotting assay
 
Schedule:
Tested every Tuesday and Friday
Note: If not delivered at the time of testing, will be done in the next round.
 
Turnaround Time:
Collected specimen to report within 4 days
 
Performing Location:
Hematology, Laboratory Department Tel. 17254
 
Specimen Retention Time:
14 days
 
 
 
Test Code:
PS

Order Name:
Protein S

 
 
Clinical Information:
Protein S is a vitamin K-dependent cofactor for the anticoagulant and the profibrinolytic effects of activated Protein C. Two forms of Protein S are present in plasma: free Protein S (40%), and Protein S linked to the complement C4b-binding protein (C4BP) (60%).

The presence of free Protein S is determined by measuring the increase of turbidity produced by the agglutination of two latex reagents. Purified C4BP adsorbed onto the first latex reagent reacts with a high affinity for free Protein S of patient plasma in the presence of Ca2+ ions. The free Protein S adsorbed on the C4BP latex triggers the agglutination reaction with the second latex reagent which is sensitized with a monoclonal antibody directed against human Protein S. The degree of agglutination will be directly proportional to the free Protein S concentration in the test sample.
 
Reference Value:
Sex Reference Value Unit
Male 74.1 - 146.1 % Activity
Female 54.7 - 123.7 % Avtivity
 
Clinical Reference:
  1. Manufacturer’s reagent Package Insert, Free Protein S HemosIL®, Instrumentation Laboratory Company -Bedford, MA 01730-2443 (USA), Instrumentation Laboratory SpA-V.le Monza 338 - 20128 Milano (Italy), 02/2016
  2. https://www.mayocliniclabs.com (Retrieved: 22 Jan 2019)