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Test Code:
PC

Order Name:
Protein C

 
Useful For:
As an initial test for evaluating patients suspected of having congenital protein C deficiency, including those with personal or family histories of thrombotic events.
 
Methodology:
Chromogenic substrate
 
AliasesName:
Functional Protein C
Protein C Functional, Plasma
 
 
 
Test Code:
PC

Order Name:
Protein C

 
Collection Specimen Or Container:
Blood/ Sodium citrate tube (Sodium Citrate 3.2% anticoagulant, Blue top) 3 mL, 2 tubes
 
Specimen Testing Type:
Citrate plasma, minimum volume 0.5 mL
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Hemolysis: Hemoglobin >500 mg/dL will be reject.
Lipemia: Triglyceride >890 mg/dL will be reject.
Icterus: Bilirubin >21 mg/dL will be reject.
Other: Clotted specimen will be rejected.
 
Specimen Stabillity:
Specimen Type Temperature Time
Whole blood, Sodium citrate Room temperature, 18oC to 25oC 4 hours
Plasma, Sodium citrate Room temperature, 18oC to 25oC 4 hours
Refrigerated, 2oC to 8oC 4 hours
Frozen, -20oC 2 weeks
Frozen, -70oC 1 year
 
 
 
Test Code:
PC

Order Name:
Protein C

 
Method detail:
Chromogenic substrate
 
Schedule:
Tested every Tuesday and Friday
Note: If not delivered at the time of testing, will be done in the next round
 
Turnaround Time:
Collected specimen to report within 4 days
 
Performing Location:
Hematology, Laboratory Department Tel. 17254
 
Specimen Retention Time:
14 days
 
 
 
Test Code:
PC

Order Name:
Protein C

 
 
Clinical Information:
Protein C is a vitamin K dependent protein that is present in plasma as a zymogen. Protein C is activated in vivo by thrombin in the presence of thrombomodulin. Protein C can be activated in vitro by a protein fraction derived from the venom of the copperhead snake Agkistrodon contortrix contortrix. Deficiency of Protein C is associated with recurrent venous thrombosis, especially in young adults. Acquired deficiencies of Protein C are associated with hepatic disorders, oral anticoagulant therapy, and disseminated intravascular coagulation
 
Reference Value:
70 - 140% Activity
 
Clinical Reference:
  1. Manufacturer’s reagent Package Insert, Protein C HemosIL®, Instrumentation Laboratory Company - Bedford, MA 01730-2443 (USA), Instrumentation Laboratory SpA - V.le Monza 338 - 20128 Milano (Italy),03/2016
  2. https://www.mayocliniclabs.com (Retrieved: 22 Jan 2019)
  3. http://online.lexi.com (Retrieved: 22 Jan 2019)