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Test Code:
PROL

Order Name:
Prolactin

 
Useful For:
Determination of prolactin in human serum.

An aid in the diagnosis of male and female infertility and pituitary dysfunction, monitoring of male and female gonadal disorders and management of amenorrhea and galactorrhea.
 
Methodology:
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
 
 
Test Code:
PROL

Order Name:
Prolactin

 
Collection Specimen Or Container:
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 1 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: 4+ reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum (keep in original tube) Room temperature, 20oC to 28oC 8 hours
Serum Refrigerated, 2oC to 8oC 7 days
Frozen, -10oC 12 months
 
 
 
Test Code:
PROL

Order Name:
Prolactin

 
Method detail:
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
Schedule:
Tested Daily (24 Hours)
 
Turnaround Time:
Specimen collected to reported within 2:00 Hours (120 Mins)
 
Performing Location:
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
PROL

Order Name:
Prolactin

 
 
Clinical Information:
 Human prolactin (hPRL) is a single chain polypeptide of 199 amino acids and a molecular weight of approximately 23,000 daltons. Its existence as a distinct chemical entity, separate from growth hormone, was established through a series of studies between 1965 and 1971. Prolactin is produced by the anterior pituitary and its secretion is regulated physiologically by inhibitory and releasing  factors of the hypothalamus. Prolactin appears in the blood promptly after administration of thyrotropin-releasing hormone (TRH). The major physiologic action of prolactin is the initiation and maintenance of lactation in women.

Hyperprolactinemia has been established as a common cause of infertility and gonadal disorders in men and women. Prolactin has been shown to inhibit the secretion of ovarian steroids  and to interfere with follicle
maturation  and the secretion of LH and FSH  in the human female. Measurement of elevated serum prolactin levels may provide the first quantitative evidence of pituitary dysfunction. Quantitation of prolactin levels is also of interest in the evaluation and management of patients with amenorrhea and galactorrhea.

Various factors other than disease states have been found to influence prolactin levels. Factors which increase prolactin concentrations include: pregnancy, breast stimulation, stress, coitus, administration of estrogens, progesterone, androgens, some psychotropic and antihypertensive drugs, and TRH. Factors which decrease prolactin concentrations include the administration of L-dopa and bromocriptine.
 
 
Reference Value:
Men : 3.46 – 19.40  ng/mL 
Women : 5.18 – 26.53 ng/mL
 
Clinical Reference:
Manufacturer’s Reagent package insert Architect Prolactin, January 2016,  Abbott Ireland Diagnostics Division, Lisnamuck, Longford Co.,Longford,Ireland