Test Code (รหัสการทดสอบ):
Order Name (ชื่อการทดสอบ):
Clinical Information (ข้อมูลทางคลินิก):
Procalcitonin (PCT) is a 116 amino acid protein prohormone of calcitonin (CT). Under normal metabolic conditions, hormonally active CT is produced and secreted in the C-cells of the thyroid gland after specific intracellular proteolytic activity. In healthy individuals, the intact PCT is not secreted from the thyroid and levels
in the blood are very low.
Response to inflammatory stimuli, including bacterial infections, induces an increased expression of the CALC-I gene with production and secretion of intact PCT from all parenchymal tissues and differentiated cell types throughout the body. An increase in circulating PCT can be observed 2–4 hours after bacterial induction and may increase to levels up to several hundred ng/mL in severe sepsis and septic shock. PCT levels rise rapidly,
reaching a plateau after 6–12 hours. PCT concentrations remain high for up to 48 hours, falling to their baseline values over several days if the infection is controlled. The half-life of PCT is about 24–30 hours.
Reference Value (ค่าอ้างอิง):
< 0.5 ng/mL representa low risk of severe sepsis and/or septic shock
> 2.0 ng/mL represent a high risk of severe sepsis and/or septic shock
Clinical Reference (เอกสารอ้างอิง):
Manufacturer’s Reagent package insert Architect B∙R∙A∙H∙M∙S PCT, Abbott GmbH & Co. KG Max-Planck-Ring 2 65205 Wiesbaden Germany, December 2016.