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Test Code:
PROCAL

Order Name:
Procalcitonin

 
Useful For:
  • Determination of PCT (procalcitonin) in human serum and plasma. 
  • Used to aid in the early detection of clinically relevant bacterial infections. 
 
Methodology:
Electrochemiluminescence method (ECLIA)
 
AliasesName:
PCT
 
 
 
Test Code:
PROCAL

Order Name:
Procalcitonin

 
Collection Specimen Or Container:
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 1 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: 4+ reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum (keep in original tube) Room temperature, 20oC to 28oC 8 hours
Serum Refrigerated, 2oC to 8oC 1 day
Frozen, -20oC 3 months
 
 
 
Test Code:
PROCAL

Order Name:
Procalcitonin

 
Method detail:
Electrochemiluminescence method (ECLIA)
 
Schedule:
Tested Daily (24 Hours)
 
 
Turnaround Time:
Specimen collected to reported within 2:00 Hours (120 Mins)
 
Performing Location:
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
PROCAL

Order Name:
Procalcitonin

 
 
Clinical Information:
Procalcitonin (PCD is a 116 amino acid prohormone with a molecular weight of approximately 12.7 kDa. PCT is expressed by neuroendocrine cells (C cells of the thyroid, pulmonary and pancreatic tissues) and successively enzymatically cleaved into (immature) calcitonin, katacalcin, and an N-terminal region. The blood of healthy individuals contains only low levels of PCT. It was discovered that PCT increases during bacterial infection. 

Increased PCT levels are often found in patients sufferin~ from bacterial sepsis, especially severe sepsis and septic shock.o PCT is considered as a prognostic marker to support outcome prediction in sepsis patients.
In acute pancreatitis PCT was found to be a reliable indicator of severity and of major complications. In patients suffering from community-acquired respiratory tract infections or ventilator-induced pneumonia PCT has been proposed as a guide for the decision of antibiotic treatment necessity and to monitor treatment success.
 
Reference Value:
< 0.5 ng/mL representa low risk of severe sepsis and/or septic shock
> 2.0 ng/mL represent a high risk of severe sepsis and/or septic shock
 
Clinical Reference:
Manufacturer’s reagent package insert, Elecsys and cobas e analyzers PCT, 2019-01, V11.0, Roche Diagnostics GmbH, D-28305 Mannheim.