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Clear
 
Test Code:
090-71-5002

Order Name:
Pharmacogenomics in HLA-B **

 
Useful For:
Reduce risks of drug-induced hypersensitivity by HLA-B genotyping test
HLA-B*13:01 before Dapsone, Co-trimoxazole therapy 
HLA-B*15:02 before Carbamazepine, Oxcarbazepine, Phenytoin, Co-trimoxazole therapy 
HLA-B*35:05 before Nevirapine therapy 
HLA-B*57:01 before Abacavir therapy 
HLA-B*58:01 before Allopurinol therapy
 
Methodology:
Polymerase Chain Reaction (PCR)/Sequence-Specific Oligonucleotide Probes (SSO)
 
Test List In Profile:
HLA-B*13:01 
HLA-B*15:02 
HLA-B*35:05 
HLA-B*57:01 
HLA-B*58:01 
 
 
AliasesName:
Pharmacogenetic for HLA B
Drug - induced Hypersensitivity
Phenytoin Carbamazepine Co-trimoxazole Oxcarbazepine Dapsone Nevirapine Abacavir Allopurinol Hypersensitivity
HLA-B
B1301 
B1502 
B3505 
B5701 
B5801 
 
 
 
Test Code:
090-71-5002

Order Name:
Pharmacogenomics in HLA-B **

 
Collection Specimen Or Container:
Blood/ K3 EDTA (Lavender Top) 3 mL, 2 tubes
 
Specimen Testing Type:
Whole Blood EDTA, minimum volume 3 mL
 
Sub Mission Container:
Original tube
 
Rejection Criteria:
Hemolysis: Hemolysis interfere
Other: Over Stability will be reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Whole blood, EDTA Ambient  Same day
Refrigerated, 2oC to 8oC 7 days
 
 
 
Test Code:
090-71-5002

Order Name:
Pharmacogenomics in HLA-B **

 
Method detail:
PCR sequence-specific oligonucleotide probes (SSOPs)
 
Schedule:
N/A **Sent Out to Ramathibodi
 
Turnaround Time:
Reported within 3-5 days (exception for official holidays)
 
Performing Location:
Ramathibodi
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
090-71-5002

Order Name:
Pharmacogenomics in HLA-B **

 
 
Clinical Information:
HLA-B Genotyping for determining human leukocyte antigens (HLA) type that related to the risk of drug-induced hypersensitivity;
  • HLA-B*13:01 before Dapsone therapy (Leprosy drug, antibiotics)
  • HLA-B*15:02 before Carbamazepine, Oxcarbazepine, Phenytoin, Co-trimoxazole therapy (seizures, neuropathic pain, trigeminal neuralgia drug)
  • HLA-B*35:05 before Nevirapine therapy (HIV/AIDS drug)
  • HLA-B*57:01 before Abacavir therapy (HIV/AIDS drug)
  • HLA-B*58:01 before Allopurinol therapy (Gout drug)
For Positive result, should follow Guidelines from the Clinical Pharmacogenomics Implementation Consortium (CPIC).
 
Reference Value:
Negative
 
Interpretation:
An interpretive report will be provided.
 
Clinical Reference:
1. http://ppmrama.com/the-pharmaceutical-laboratory-of-genetics (Retrieved: 27 Apr 2020)
2. www.si.mahidol.ac.th (Retrieved: 18 Jan 2019)