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Clear
 
Test Code:
090-71-5007

Order Name:
Pharmacogenetics in NUDT15 **

 
Useful For:

Predicting potential for toxicity to thiopurine drugs (6-mercaptopurine, 6-thioguanine, and azathioprine)

ใช้เป็นข้อมูลทางเภสัชพันธุศาสตร์ของผู้ป่วย เพื่อประกอบการให้ปริมาณ (dose) ของยา Thiopurine ที่เหมาะสมกับแต่ละบุคคล
NUDT deficiency is most common among East Asians, followed by South Asians, and Native American populations. 

 
Methodology:
Genotyping by PCR
 
AliasesName:
NUDT15 Genotyping
PGx in NUDT15
Drug-gene NUDT15
 
 
 
Test Code:
090-71-5007

Order Name:
Pharmacogenetics in NUDT15 **

 
Patient Preparation:
N/A
 
Collection Specimen Or Container:
Blood/ K3 EDTA (Lavender Top) 3 mL, 1 tube

 
 
Specimen Testing Type:
Whole Blood EDTA, minimum volume 2 mL
 
Sub Mission Container:
Original tube
 
Rejection Criteria:
Hemolysis: Hemolysis interfere
Other: Over Stability / Frozen specimen will be reject.
 
Specimen Stabillity:
Specimen Type Temperature Time
Whole blood, EDTA Ambient  Same day
Refrigerated, 2oC to 8oC 7 days

 
 
 
 
Test Code:
090-71-5007

Order Name:
Pharmacogenetics in NUDT15 **

 
Method detail:
Genotyping by PCR
 
Schedule:
N/A **Sent Out to Ramathibodi
 
Turnaround Time:
Received specimen to report within 3-5 days
(exception for official holidays)
 
Performing Location:
Ramathibodi
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
090-71-5007

Order Name:
Pharmacogenetics in NUDT15 **

 
 
Clinical Information:
Nudix hydrolase (NUDT15) is thought to dephosphorylate the active metabolites of thiopurines, TGTP and TdGTP, which prevents their incorporation into DNA and decreases their cytotoxic effects. Genetic variants in NUDT15 that decrease this activity are strongly associated with thiopurine-related myelosuppression. NUDT deficiency is most common among East Asians (22.6%), followed by South Asians (13.6%), and Native American populations (12.5%-21.2%). Studies in other populations are ongoing. This test evaluates variants associated with NUDT15*2, NUDT15*3, NUDT15*4, and NUDT15 *5. If no NUDT15 variant alleles are detected by this assay, the most likely genotype is that of NUDT15*1/*1 although the presence of other rarer alleles cannot be excluded. Individuals with variants in both TPMT and NUDT15 have been identified and were significantly more sensitive to mercaptopurine than individuals with variants in only 1 gene. Integration of both TPMT and NUDT15 testing may allow for more accurate prediction of thiopurine-related toxicity risk to guide dosing, particularly among patients from diverse populations.
 
Clinical Reference:
Ramathibodi Laboratory Guide book 2560-2562