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Clear
 
Test Code:
090-31-2430-01

Order Name:
Parietal Cell Antibody **

 
Useful For:
Evaluating patients suspected of having pernicious anemia or immune-mediated deficiency of vitamin B12 with or without megaloblastic anemia
 
Methodology:
Enzyme-Linked Immunosorbent Assay (ELISA)
 
AliasesName:
PCAB
Parietal Cell Antibodies, IgG, Serum
Gastric Parietal Cell
 
 
 
Test Code:
090-31-2430-01

Order Name:
Parietal Cell Antibody **

 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 5 mL, 2 tubes
 
Specimen Testing Type:
Serum, minimum volume 2 mL
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Hemolysis: Mild OK; Gross reject
Lipemia: Mild OK; Gross reject
Icterus: Mild OK; Gross OK
Other: Heat-treated specimen will be reject.
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Refrigerated (preferred), 2oC to 8oC 21 days
Frozen 21 days
 
 
 
Test Code:
090-31-2430-01

Order Name:
Parietal Cell Antibody **

 
Method detail:
Enzyme-Linked Immunosorbent Assay (ELISA)
 
Schedule:
N/A **Sent out to MAYO, USA
 
Turnaround Time:
14 days
 
Performing Location:
MAYO Laboratory
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
090-31-2430-01

Order Name:
Parietal Cell Antibody **

 
 
Clinical Information:
Pernicious anemia (PA) is characterized by atrophic body gastritis (ABG) and is the end state of a progressive disease known as autoimmune chronic atrophic gastritis. In this disease, immune-mediated inflammation leads to destruction of gastric parietal cells with the resultant loss of intrinsic factor production and the inability to absorb dietary vitamin B12. Diagnosis of PA involves demonstrating the presence of a macrocytic anemia in the context of vitamin B12 deficiency, as well as documenting positive autoantibody serology, specifically anti-parietal cell antibody (PCA) and intrinsic factor antibody (IFA).
 
Reference Value:
Negative: ≤ 20.0 Units
Equivocal: 20.1-24.9 Units
Positive: ≥ 25.0 Units
Reference values apply to all ages.
 
Interpretation:
A positive result indicates the presence of IgG antibodies to H(+)/K(+) ATPase and suggests the possibility of pernicious anemia (PA) or a related autoimmune disease. A negative result indicates no detectable IgG antibodies to H(+)/K(+) ATPase; it does not rule out PA. An equivocal result is indeterminate.
 
Clinical Reference:
www.mayomedicallaboratories.com (Retrieved: 24 Jan 2019)