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Test Code:
090-31-4010

Order Name:
Parathyroid Hormone-Related Peptide (PTHrP), Plasma **

 
Useful For:

Aiding in the evaluation of patients with hypercalcemia of unknown origin

Aiding in the evaluation of patients with suspected humoral hypercalcemia of malignancy

The test should not be used to exclude cancer or screen tumor patients for humoral hypercalcemia of malignancy.

 
Methodology:
Immunochemiluminometric Assay (ICMA)
 
AliasesName:
Humoral Hypercalcemia of Malignancy Factor
Parathyroid Related Polypeptide
Parathyroid Related Protein
PRP
PTH Related Peptide
PTHRP, Plasma
PTH Related Protein
Parathyroid Hormone Related Peptide
 
 
 
Test Code:
090-31-4010

Order Name:
Parathyroid Hormone-Related Peptide (PTHrP), Plasma **

 
Collection Specimen Or Container:
Blood/  Ice-cooled EDTA (Lavender Top) 3 mL, 2 tubes
ให้นำเอา tube EDTA ไปแช่น้ำแข็ง/ตู้เย็น  5 นาทีก่อนนำมาใช้เจาะเลือด
 
Specimen Testing Type:
Plasma EDTA, minimum volume 0.5 mL x 2 tubes
Instructions:
1. Centrifuge specimen in a refrigerated centrifuge or in chilled centrifuge cups.
2. Aliquot plasma into plastic vial and freeze.
 
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK
 
Specimen Stabillity:
Specimen Type Temperature Time
Plasma EDTA
Frozen 30 days
 
 
 
Test Code:
090-31-4010

Order Name:
Parathyroid Hormone-Related Peptide (PTHrP), Plasma **

 
Method detail:
Immunochemiluminometric Assay (ICMA)
 
Schedule:
N/A **Sent out to MAYO, USA
 
Turnaround Time:
Received specimen to reported within 14 days
(exception for official holidays)
 
Performing Location:
MAYO Laboratory
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
090-31-4010

Order Name:
Parathyroid Hormone-Related Peptide (PTHrP), Plasma **

 
 
Clinical Information:
Parathyroid hormone-related peptide (PTHrP) exists in several isoforms, ranging in size from 60 to 173 amino acids, which are created by differential splicing and post-translational processing by prohormone convertases. PTHrP is produced in low concentrations by virtually all tissues. The N-terminus and the secondary structure of multiple isoforms of PTHrP resemble parathyroid hormone (PTH), allowing PTHrP to bind to the same receptor as PTH. The physiological role of PTHrP can be divided into 5 categories: 1) transepithelial calcium transport, particularly in the kidney and mammary gland; 2) smooth muscle relaxation in the uterus, bladder, gastrointestinal tract, and arterial wall; 3) regulation of cellular proliferation; 4) cellular differentiation and apoptosis of multiple tissues; and 5) as an indispensable component of successful pregnancy and fetal development (embryonic gene deletion is lethal in mammals).
 
Reference Value:
< or =4.2 pmol/L
 
Interpretation:

Depending on the patient population, up to 80% of patients with malignant tumors and hypercalcemia will be suffering from humoral hypercalcemia of malignancy (HHM). Of these, 50% to 70% might have an elevated parathyroid hormone-related peptide (PTHrP) level. These patients will also usually show typical biochemical changes of excess parathyroid hormone (PTH)-receptor activation, namely, besides the hypercalcemia, they might have hypophosphatemia, hypercalcuria, hyperphosphaturia, and elevated serum alkaline phosphatase. Their PTH levels will typically be less than 30 pg/mL or undetectable.

In patients with biochemical findings that suggest, but do not prove, primary hyperparathyroidism (eg, hypercalcemia, but normal or near-normal serum phosphate, and a PTH level that is within the population reference range but above 30 pg/mL), HHM should be considered as a diagnostic possibility, particularly if the patient is elderly, has a history of malignancy, or risk factors for malignancy. An elevated PTHrP level in such a patient is highly suggestive of HHM as the cause for the hypercalcemia.

 
Clinical Reference:
www.mayocliniclabs.com (Retrieved: 1 July 2020)