Package GenomeHealth-Premium

Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):

Blood/ K3 EDTA (K3E) (Lavender Top) 3 mL, 2 tube

Document required:
For BH:
1. Consent for Genetic Testing (PGM-00101)
2. Questionnaire for WES and WGS screening test (TrakCare)

For B2B:
1. Requisition and Consent Form for WES or WGS screening, Please click LINK

Turnaround Time (ระยะเวลารอผล):

Report within 6-8 weeks

Useful For (ประโยชน์การทดสอบ):

This test is suitable for individuals with a personal or family history of certain cancers or hereditary conditions, as well as those who wish to understand their genetic predisposition to cancer, cardiovascular diseases, malignant hyperthermia (a severe reaction to anesthesia), additional potential conditions (Additional Findings).

The package also offers a comprehensive DNA All Health Report and a specialized report for long-term brain health planning.

Methodology (วิธีการทดสอบ):

1. Next generation sequencing (NGS), Whole genome sequencing (WGS)
2. SNP genotyping for DNA All Health Report using open array technology

Test List In Profile (การทดสอบใน Profile):

WGS screening panel
1. Cancer screen report
2. Cardio screen report
3. Malignant Hyeprthermia report
4.Additional finding report

SNP microarray
5. GenomeHealth SNP&Pick **

AliasesName (ชื่อเรียกอื่นๆ) :

Whole exome sequencing, WES, cancer, genetic, cardio,Malignant Hyperthermia

Test Code (รหัสการทดสอบ):

LAB64

Order Name (ชื่อการทดสอบ):

Package GenomeHealth-Premium

Patient Preparation (การเตรียมตัวผู้ป่วย):

Preparation not required

Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):

Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):

Whole blood, K3 EDTA (K3E) (Lavender Top) 3 mL

Sub Mission Container (ภาชนะส่งตรวจ):

K3 EDTA (K3E) (Lavender Top)

Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):

Use heparin as anticoagulant,
Severe clotted specimen

Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):

EDTA Whole Blood, Refrigerated 2°C to 8°C for 7 days

Test Code (รหัสการทดสอบ):

LAB64

Order Name (ชื่อการทดสอบ):

Package GenomeHealth-Premium

Turnaround Time (ระยะเวลารอผล):

Report within 6-8 weeks

Performing Location (หน่วยงานที่ทำการทดสอบ):

Laboratory – Clinical Genomics Tel 14252, 14596

Specimen Retention Time (ระยะเวลาเก็บสิ่งส่งตรวจ):

3 months

Test Code (รหัสการทดสอบ):

LAB64

Order Name (ชื่อการทดสอบ):

Package GenomeHealth-Premium

Clinical Information (ข้อมูลทางคลินิก):

GenomeHealth-Premium empowers you to take a proactive approach to health management through comprehensive genetic data from Whole Genome Sequencing (WGS), enabling the assessment of risks for major diseases.
It also provides a personalized DNA All Health report, guiding you to adjust your lifestyle and behaviors in alignment with your genetic profile, helping you take control of your health and achieve lasting well-being.

GenomeHealth-Premium is a comprehensive testing package that evaluates risks across four major disease groups, including cancer, cardiovascular diseases, Malignant Hyperthermia (a severe reaction to anesthesia), and additional findings related to other potential health conditions. The package also includes a personalized DNA All Health Report, offering in-depth analysis of nutrition, exercise, and lifestyle behaviors tailored to your genetic profile.

There are 5 reports included in the test.
1.Cancer screening report: analyze 92 genes and report for 18 cancer types includes Breast Cancer, Ovarian Cance, Uterine Cancer, Colorectal Cancer, Cutaneous melanoma, Gastric Cancer, Pancreatic Cancer, Prostate Cancer, Renal cell cancer, Thyroid Cancer, Sarcoma, Leukemia, Brain cancer, Lung cancer, Endocrine cancer, Neuroendocrine, Retinoblastoma and Other related syndromes
2.Cardio screening report: analyze 98 genes and report for 6 cardio conditions includes Aortopathy, Arrhythmias, Cardiomyopathies, Genetic forms of high blood pressure and high cholesterol, Hereditary Hemorrhagic Telangiectasia and Thrombophilia
3.Malignant hyperthermia report: Analyzes 3 genes related to Malignant Hyperthermia condition.
4.Additional findings report: Analyzes 16 genes and reports on 11 additional conditions related to inborn errors of metabolism and miscellaneous phenotypes
5.GenomeHealth SNP&Pick: Provides personalized recommendations on nutrition, exercise, and lifestyle adjustments tailored to your genetic profile, empowering you to live in harmony with your body.

Clinical Reference (เอกสารอ้างอิง):

1. https://www.omim.org (Retrieved 1 July 2022)
2.https://www.cancer.gov/publications/dictionaries/cancer-terms/def/inherited-cancer-syndrome ((Retrieved 1 July 2022)
3. Cirino AL, Harris S, Lakdawala NK, et al. Role of Genetic Testing in Inherited Cardiovascular Disease: A Review. JAMA Cardiol. 20172(10):1153-1160. doi:10.1001/jamacardio.2017.2352
4. Gonsalves, Stephen G., et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for the use of potent volatile anesthetic agents and succinylcholine in the context of RYR 1 or CACNA 1S genotypes. Clinical Pharmacology & Therapeutics 105.6 (2019): 1338-1344.