bih.button.backtotop.text
BROWSE BY TEST NAME
%
1
2
3
5
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Clear
 
Test Code:
092-10-0018

Order Name:
Oncomine Comprehensive Plus (517 Genes) - FFPE

 
Useful For:
The detection of SNVs, InDels, CNVs, gene fusions, Tumor Mutational Burden (TMB) and Microsatellite Status (MSI). The detection of known and novel biomarkers associated with targeted and immuno-oncology therapies covers 517 genes associated with a variety of tumor types.

Gene List:
- Coding sequence (CDS) only genes:
     CALR, CIITA, CYP2D6, ERCC5, FAS, ID3, KLHL13, MTUS2, PSMB10, PSMB8, PSMB9,
     RNASEH2C, RPL22, RPL5, RUNX1T1, SDHC, SOCS1, STAT1, TMEM132D, UGT1A1, ZBTB20

- Hotspot genes:
     ACVR1, ATP1A1, BCR, BMP5, BTK, CACNA1D, CD79B, CSF1R, CTNNB1, CUL1, CYSLTR2,
     DGCR8, DROSHA, E2F1, EPAS1, FGF7, FOXL2, FOXO1, GLI1, GNA11, GNAQ, HIF1A,
     HIST1H2BD, HIST1H3B, HRAS, IDH1, IL6ST, IRF4, IRS4, KLF4, KNSTRN, MAP2K2, MED12,
     MYOD1, NSD2, NT5C2, NTRK2, NUP93, PAX5, PIK3CD, PIK3CG, PTPRD, RGS7, RHOA,
     RPL10, SIX1, SIX2, SNCAIP, SOS1, SOX2, SRSF2, STAT5B, TAF1, TGFBR1, TRRAP, TSHR,
     WAS

- Hotspot Genes and Copy Number Variation:
     ABL1, ABL2, AKT1, AKT2, AKT3, ALK, AR, ARAF, AURKA, AURKC, AXL, BCL2, BCL2L12, BCL6,
     BRAF, CARD11, CBL, CCND1, CCND2, CCND3, CCNE1, CDK4, CDK6, CHD4, DDR2, EGFR,
     EIF1AX, ERBB2, ERBB3, ERBB4, ESR1, EZH2, FAM135B, FGFR1, FGFR2, FGFR3, FGFR4, FLT3,
     FLT4, FOXA1, GATA2, GNAS, H3F3A, H3F3B, IDH2, IKBKB, IL7R, KDR, KIT, KLF5, KRAS,
     MAGOH, MAP2K1, MAPK1, MAX, MDM4, MECOM, MEF2B, MET, MITF, MPL, MTOR, MYC,
     MYCN, MYD88, NFE2L2, NRAS, NTRK1, NTRK3, PCBP1, PDGFRA, PDGFRB, PIK3C2B,
     PIK3CA, PIK3CB, PIK3R2, PIM1, PLCG1, PPP2R1A, PPP6C, PRKACA, PTPN11, PXDNL, RAC1,
     RAF1, RARA, RET, RHEB, RICTOR, RIT1, ROS1, SETBP1, SF3B1, SLCO1B3, SMC1A, SMO,
     SPOP, SRC, STAT3, STAT6, TERT, TOP1, TPMT, U2AF1, USP8, XPO1, ZNF217, ZNF429

- CNV Gain Genes:
     ABCB1, CTNND2, DDR1, EMSY, FGF19, FGF23, FGF3, FGF4, FGF9, FYN, GLI3, IGF1R, MCL1,
     MDM2, MYCL, RPS6KB1, RPTOR, YAP1, YES1

- CNV Loss and Coding sequence (CDS):
     ABRAXAS1, ACVR1B, ACVR2A, ADAMTS12, ADAMTS2, AMER1, APC, ARHGAP35, ARID1A,
     ARID1B, ARID2, ARID5B, ASXL1, ASXL2, ATM, ATR, ATRX, AXIN1, AXIN2, B2M, BAP1, BARD1,
     BCOR, BLM, BMPR2, BRCA1, BRCA2, BRIP1, CASP8, CBFB, CD274, CD276, CDC73, CDH1,
     CDH10, CDK12, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CHEK1, CHEK2, CIC,
     CREBBP, CSMD3, CTCF, CTLA4, CUL3, CUL4A, CUL4B, CYLD, CYP2C9, DAXX, DDX3X,
     DICER1, DNMT3A, DOCK3, DPYD, DSC1, DSC3, ELF3, ENO1, EP300, EPCAM, EPHA2, ERAP1,
     ERAP2, ERCC2, ERCC4, ERRFI1, ETV6, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG,
     FANCI, FANCL, FANCM, FAT1, FBXW7, FUBP1, GATA3, GNA13, GPS2, HDAC2, HDAC9, HLA-A,
     HLA-B, HNF1A, INPP4B, JAK1, JAK2, JAK3, KDM5C, KDM6A, KEAP1, KMT2A, KMT2B, KMT2C,
     KMT2D, LARP4B, LATS1, LATS2, MAP2K4, MAP2K7, MAP3K1, MAP3K4, MAPK8, MEN1, MGA,
     MLH1, MLH3, MRE11, MSH2, MSH3, MSH6, MTAP, MUTYH, NBN, NCOR1, NF1, NF2,
     NOTCH1, NOTCH2, NOTCH3, NOTCH4, PALB2, PARP1, PARP2, PARP3, PARP4, PBRM1,
     PDCD1, PDCD1LG2, PDIA3, PGD, PHF6, PIK3R1, PMS1, PMS2, POLD1, POLE, POT1, PPM1D,
     PPP2R2A, PRDM1, PRDM9, PRKAR1A, PTCH1, PTEN, PTPRT, RAD50, RAD51, RAD51B,
     RAD51C, RAD51D, RAD52, RAD54L, RASA1, RASA2, RB1, RBM10, RECQL4, RNASEH2A,
     RNASEH2B, RNF43, RPA1, RUNX1, SDHA, SDHB, SDHD, SETD2, SLX4, SMAD2, SMAD4,
     SMARCA4, SMARCB1, SOX9, SPEN, STAG2, STK11, SUFU, TAP1, TAP2, TBX3, TCF7L2, TET2,
     TGFBR2, TNFAIP3, TNFRSF14, TP53, TP63, TPP2, TSC1, TSC2, USP9X, VHL, WT1, XRCC2,
     XRCC3, ZFHX3, ZMYM3, ZRSR2

- Gene Fusions:
     AKT2, ALK, AR, AXL, BRAF, BRCA1, BRCA2, CDKN2A, EGFR, ERBB2, ERBB4, ERG, ESR1, ETV1,
     ETV4, ETV5, FGFR1, FGFR2, FGFR3, FGR, FLT3, JAK2, KRAS, MDM4, MET, MYB, MYBL1, NF1,
     NOTCH1, NOTCH4, NRG1, NTRK1, NTRK2, NTRK3, NUTM1, PDGFRA, PDGFRB, PIK3CA,
     PPARG, PRKACA, PRKACB, PTEN, RAD51B, RAF1, RB1, RELA, RET, ROS1, RSPO2, RSPO3,
     TERT

- Tumor Mutational Burden (TMB) only genes:
     A1CF, ACSM2B, ADAM18, ANO4, ARMC4, BRINP3, C6, C8A, C8B, CANX, CASR, CD163,
     CNTN6, CNTNAP4, CNTNAP5, COL11A1, DCAF4L2, DCDC1, GALNT17, GPR158, GRID2,
     HCN1, HLA-C, KCND2, KCNH7, KEL, KIR3DL1, KRTAP2-1, KRTAP6-2, LRRC7, MARCO,
     NLRC5, NOL4, NRXN1, NYAP2, OR10G8, OR2G6, OR2L13, OR2L2, OR2L8, OR2M3, OR2T3,
     OR2T33, OR2T4, OR2W3, OR4A15, OR4C15, OR4C6, OR4M1, OR4M2, OR5D18, OR5F1,
     OR5L1, OR5L2, OR6F1, OR8H2, OR8I2, OR8U1, ORC4, PAK5, PCDH17, PDE1A, PDE1C,
     PLXDC2, POM121L12, PPFIA2, RBP3, REG1A, REG1B, REG3A, REG3G, RPTN, RUNDC3B,
     SH3RF2, SLC15A2, SLC8A1, SYT10, SYT16, TAPBP, TPTE, TRHDE, TRIM48, TRIM51, ZIM3,
     ZNF479, ZNF536
 
Methodology:
Next generation sequencing (NGS), Target sequencing
 
AliasesName:
FFPE tissue mutation
 
 
 
Test Code:
092-10-0018

Order Name:
Oncomine Comprehensive Plus (517 Genes) - FFPE

 
Collection Specimen Or Container:
Tissue/ Formalin-fixed paraffin-embedded (FFPE) block
 
Specimen Testing Type:
Tissue, Formalin-fixed paraffin-embedded (FFPE) block,
5 x 10 µm FFPE tissue section, 25 – 300 mm² (≥ 10% Neoplastic cell content)
 
Sub Mission Container:
Tissue/ Formalin-fixed paraffin-embedded (FFPE) block
 
Rejection Criteria:
Neoplastic cell content <10%
 
Specimen Stabillity:
Specimen Type Temperature Time
FFPE Tissue section Ambient 1 month
 
 
 
Test Code:
092-10-0018

Order Name:
Oncomine Comprehensive Plus (517 Genes) - FFPE

 
Method detail:
Next generation sequencing (NGS), Target sequencing
 
Turnaround Time:
Reported within 20 days
 
Performing Location:
Research and Development Tel. 14252
 
Specimen Retention Time:
1 month
 
 
 
Test Code:
092-10-0018

Order Name:
Oncomine Comprehensive Plus (517 Genes) - FFPE

 
 
Clinical Information:
Oncomine Comprehensive Plus (517 Genes) - FFPE assay contains targeted, multi-biomarker panels that enable simultaneous detection of hundreds of variants across >500 genes relevant to solid tumors. The assay addresses mutiple biomarkers associated with targeted and immune checkpoint therapies. It allows concurrent analysis of DNA and RNA to simultaneously detect multiple types of variants including hotspots, single nucleotide variants (SNVs), insertions and deletions (INDELs), copy number variants (CNVs), microsatellite instability status (MSI), tumor mutational burden (TMB), and gene fusions.
 
Clinical Reference:
https://www.thermofisher.com/order/catalog/product/A46721#/A46721 (Retrieved 07 Sep 2020)