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Test Code (รหัสการทดสอบ):
092-10-0018

Order Name (ชื่อการทดสอบ):
Oncomine Comprehensive Plus (517 Genes) - FFPE

 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Tissue/ Formalin-fixed paraffin-embedded (FFPE) block
 
Turnaround Time (ระยะเวลารอผล):
Reported within 20 days
 
Useful For (ประโยชน์การทดสอบ):
The detection of SNVs, InDels, CNVs, gene fusions, Tumor Mutational Burden (TMB) and Microsatellite Status (MSI). The detection of known and novel biomarkers associated with targeted and immuno-oncology therapies covers 517 genes associated with a variety of tumor types.

Gene List:
- Coding sequence (CDS) only genes:
     CALR, CIITA, CYP2D6, ERCC5, FAS, ID3, KLHL13, MTUS2, PSMB10, PSMB8, PSMB9,
     RNASEH2C, RPL22, RPL5, RUNX1T1, SDHC, SOCS1, STAT1, TMEM132D, UGT1A1, ZBTB20

- Hotspot genes:
     ACVR1, ATP1A1, BCR, BMP5, BTK, CACNA1D, CD79B, CSF1R, CTNNB1, CUL1, CYSLTR2,
     DGCR8, DROSHA, E2F1, EPAS1, FGF7, FOXL2, FOXO1, GLI1, GNA11, GNAQ, HIF1A,
     HIST1H2BD, HIST1H3B, HRAS, IDH1, IL6ST, IRF4, IRS4, KLF4, KNSTRN, MAP2K2, MED12,
     MYOD1, NSD2, NT5C2, NTRK2, NUP93, PAX5, PIK3CD, PIK3CG, PTPRD, RGS7, RHOA,
     RPL10, SIX1, SIX2, SNCAIP, SOS1, SOX2, SRSF2, STAT5B, TAF1, TGFBR1, TRRAP, TSHR,
     WAS

- Hotspot Genes and Copy Number Variation:
     ABL1, ABL2, AKT1, AKT2, AKT3, ALK, AR, ARAF, AURKA, AURKC, AXL, BCL2, BCL2L12, BCL6,
     BRAF, CARD11, CBL, CCND1, CCND2, CCND3, CCNE1, CDK4, CDK6, CHD4, DDR2, EGFR,
     EIF1AX, ERBB2, ERBB3, ERBB4, ESR1, EZH2, FAM135B, FGFR1, FGFR2, FGFR3, FGFR4, FLT3,
     FLT4, FOXA1, GATA2, GNAS, H3F3A, H3F3B, IDH2, IKBKB, IL7R, KDR, KIT, KLF5, KRAS,
     MAGOH, MAP2K1, MAPK1, MAX, MDM4, MECOM, MEF2B, MET, MITF, MPL, MTOR, MYC,
     MYCN, MYD88, NFE2L2, NRAS, NTRK1, NTRK3, PCBP1, PDGFRA, PDGFRB, PIK3C2B,
     PIK3CA, PIK3CB, PIK3R2, PIM1, PLCG1, PPP2R1A, PPP6C, PRKACA, PTPN11, PXDNL, RAC1,
     RAF1, RARA, RET, RHEB, RICTOR, RIT1, ROS1, SETBP1, SF3B1, SLCO1B3, SMC1A, SMO,
     SPOP, SRC, STAT3, STAT6, TERT, TOP1, TPMT, U2AF1, USP8, XPO1, ZNF217, ZNF429

- CNV Gain Genes:
     ABCB1, CTNND2, DDR1, EMSY, FGF19, FGF23, FGF3, FGF4, FGF9, FYN, GLI3, IGF1R, MCL1,
     MDM2, MYCL, RPS6KB1, RPTOR, YAP1, YES1

- CNV Loss and Coding sequence (CDS):
     ABRAXAS1, ACVR1B, ACVR2A, ADAMTS12, ADAMTS2, AMER1, APC, ARHGAP35, ARID1A,
     ARID1B, ARID2, ARID5B, ASXL1, ASXL2, ATM, ATR, ATRX, AXIN1, AXIN2, B2M, BAP1, BARD1,
     BCOR, BLM, BMPR2, BRCA1, BRCA2, BRIP1, CASP8, CBFB, CD274, CD276, CDC73, CDH1,
     CDH10, CDK12, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CHEK1, CHEK2, CIC,
     CREBBP, CSMD3, CTCF, CTLA4, CUL3, CUL4A, CUL4B, CYLD, CYP2C9, DAXX, DDX3X,
     DICER1, DNMT3A, DOCK3, DPYD, DSC1, DSC3, ELF3, ENO1, EP300, EPCAM, EPHA2, ERAP1,
     ERAP2, ERCC2, ERCC4, ERRFI1, ETV6, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG,
     FANCI, FANCL, FANCM, FAT1, FBXW7, FUBP1, GATA3, GNA13, GPS2, HDAC2, HDAC9, HLA-A,
     HLA-B, HNF1A, INPP4B, JAK1, JAK2, JAK3, KDM5C, KDM6A, KEAP1, KMT2A, KMT2B, KMT2C,
     KMT2D, LARP4B, LATS1, LATS2, MAP2K4, MAP2K7, MAP3K1, MAP3K4, MAPK8, MEN1, MGA,
     MLH1, MLH3, MRE11, MSH2, MSH3, MSH6, MTAP, MUTYH, NBN, NCOR1, NF1, NF2,
     NOTCH1, NOTCH2, NOTCH3, NOTCH4, PALB2, PARP1, PARP2, PARP3, PARP4, PBRM1,
     PDCD1, PDCD1LG2, PDIA3, PGD, PHF6, PIK3R1, PMS1, PMS2, POLD1, POLE, POT1, PPM1D,
     PPP2R2A, PRDM1, PRDM9, PRKAR1A, PTCH1, PTEN, PTPRT, RAD50, RAD51, RAD51B,
     RAD51C, RAD51D, RAD52, RAD54L, RASA1, RASA2, RB1, RBM10, RECQL4, RNASEH2A,
     RNASEH2B, RNF43, RPA1, RUNX1, SDHA, SDHB, SDHD, SETD2, SLX4, SMAD2, SMAD4,
     SMARCA4, SMARCB1, SOX9, SPEN, STAG2, STK11, SUFU, TAP1, TAP2, TBX3, TCF7L2, TET2,
     TGFBR2, TNFAIP3, TNFRSF14, TP53, TP63, TPP2, TSC1, TSC2, USP9X, VHL, WT1, XRCC2,
     XRCC3, ZFHX3, ZMYM3, ZRSR2

- Gene Fusions:
     AKT2, ALK, AR, AXL, BRAF, BRCA1, BRCA2, CDKN2A, EGFR, ERBB2, ERBB4, ERG, ESR1, ETV1,
     ETV4, ETV5, FGFR1, FGFR2, FGFR3, FGR, FLT3, JAK2, KRAS, MDM4, MET, MYB, MYBL1, NF1,
     NOTCH1, NOTCH4, NRG1, NTRK1, NTRK2, NTRK3, NUTM1, PDGFRA, PDGFRB, PIK3CA,
     PPARG, PRKACA, PRKACB, PTEN, RAD51B, RAF1, RB1, RELA, RET, ROS1, RSPO2, RSPO3,
     TERT

- Tumor Mutational Burden (TMB) only genes:
     A1CF, ACSM2B, ADAM18, ANO4, ARMC4, BRINP3, C6, C8A, C8B, CANX, CASR, CD163,
     CNTN6, CNTNAP4, CNTNAP5, COL11A1, DCAF4L2, DCDC1, GALNT17, GPR158, GRID2,
     HCN1, HLA-C, KCND2, KCNH7, KEL, KIR3DL1, KRTAP2-1, KRTAP6-2, LRRC7, MARCO,
     NLRC5, NOL4, NRXN1, NYAP2, OR10G8, OR2G6, OR2L13, OR2L2, OR2L8, OR2M3, OR2T3,
     OR2T33, OR2T4, OR2W3, OR4A15, OR4C15, OR4C6, OR4M1, OR4M2, OR5D18, OR5F1,
     OR5L1, OR5L2, OR6F1, OR8H2, OR8I2, OR8U1, ORC4, PAK5, PCDH17, PDE1A, PDE1C,
     PLXDC2, POM121L12, PPFIA2, RBP3, REG1A, REG1B, REG3A, REG3G, RPTN, RUNDC3B,
     SH3RF2, SLC15A2, SLC8A1, SYT10, SYT16, TAPBP, TPTE, TRHDE, TRIM48, TRIM51, ZIM3,
     ZNF479, ZNF536
 
Methodology (วิธีการทดสอบ):
Next generation sequencing (NGS), Target sequencing
 
AliasesName (ชื่อเรียกอื่นๆ) :
FFPE tissue mutation
 
 
 
Test Code (รหัสการทดสอบ):
092-10-0018

Order Name (ชื่อการทดสอบ):
Oncomine Comprehensive Plus (517 Genes) - FFPE

 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Tissue/ Formalin-fixed paraffin-embedded (FFPE) block
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Tissue, Formalin-fixed paraffin-embedded (FFPE) block,
5 x 10 µm FFPE tissue section, 25 – 300 mm², 7 slides/ribbons
(required ≥ 10% Neoplastic cell content, preferable ≥30% Neoplastic cell content)
 
Sub Mission Container (ภาชนะส่งตรวจ):
Tissue/ Formalin-fixed paraffin-embedded (FFPE) block
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):
Neoplastic cell content <10%
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
Specimen Type Temperature Time
FFPE Tissue section Ambient 1 month
 
 
 
Test Code (รหัสการทดสอบ):
092-10-0018

Order Name (ชื่อการทดสอบ):
Oncomine Comprehensive Plus (517 Genes) - FFPE

 
Method detail (วิธีการทดสอบ):
Next generation sequencing (NGS), Target sequencing
 
Turnaround Time (ระยะเวลารอผล):
Reported within 20 days
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Clinical Genomics Tel. 14252
 
Specimen Retention Time (ระยะเวลาเก็บสิ่งส่งตรวจ):
1 month
 
 
 
Test Code (รหัสการทดสอบ):
092-10-0018

Order Name (ชื่อการทดสอบ):
Oncomine Comprehensive Plus (517 Genes) - FFPE

 
 
Clinical Information (ข้อมูลทางคลินิก):
Oncomine Comprehensive Plus (517 Genes) - FFPE assay contains targeted, multi-biomarker panels that enable simultaneous detection of hundreds of variants across >500 genes relevant to solid tumors. The assay addresses mutiple biomarkers associated with targeted and immune checkpoint therapies. It allows concurrent analysis of DNA and RNA to simultaneously detect multiple types of variants including hotspots, single nucleotide variants (SNVs), insertions and deletions (INDELs), copy number variants (CNVs), microsatellite instability status (MSI), tumor mutational burden (TMB), and gene fusions.
 
Clinical Reference (เอกสารอ้างอิง):
https://www.thermofisher.com/order/catalog/product/A46721#/A46721 (Retrieved 07 Sep 2020)