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Clear
 
Test Code:
092-10-0015

Order Name:
Oncomine Comprehensive Panel (161 Genes) - FFPE

 
Useful For:
The detection of SNVs, InDels, CNVs, and gene fusions. The detection of known and novel biomarkers associated with targeted and immuno-oncology therapies covers 161 genes associated with a variety of tumor
types.
 
Gene List:
- Full-length genes:
     ARID1A, ATM, ATR, ATRX, BAP1, BRCA1, BRCA2, CDK12, CDKN1B, CDKN2A, CDKN2B, CHEK1,
     CREBBP, FANCA, FANCD2, FANCI, FBXW7, MLH1, MRE11, MSH2, MSH6, NBN, NF1, NF2,
     NOTCH1, NOTCH2, NOTCH3, PALB2, PIK3R1, PMS2, POLE, PTCH1, PTEN, RAD50, RAD51,
     RAD51C, RAD51D, RAD51B, RB1, RNF43, SETD2, SLX4, SMARCA4, SMARCB1, STK11, TP53,
     TSC1, TSC2

- Hotspot genes:
     AKT1, AKT2, AKT3, ALK, AR, ARAF, AXL, BRAF, BTK, CBL, CCND1, CDK4, CDK6, CHEK2, CSF1R,
     CTNNB1, DDR2, EGFR, ERBB2, ERBB3, ERBB4, ERCC2, ESR1, EZH2, FGFR1, FGFR2, FGFR3,
     FGFR4, FLT3, FOXL2, GATA2, GNA11, GNAQ, GNAS, H3F3A, HIST1H3B, HNF1A, HRAS, IDH1,
     IDH2, JAK1, JAK2, JAK3, KDR, KIT, KNSTRN, KRAS, MAGOH, MAP2K1, MAP2K2, MAP2K4,
     MAPK1, MAX, MDM4, MED12, MET, MTOR, MYC, MYCN, MYD88, NFE2L2, NRAS, NTRK1,
     NTRK2, NTRK3, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PPP2R1A, PTPN11, RAC1, RAF1, RET,
     RHEB, RHOA, ROS1, SF3B1, SMAD4, SMO, SPOP, SRC, STAT3, TERT, TOP1, U2AF1, XPO1

- Copy number variations genes:
     AKT1, AKT2, AKT3, ALK, AR, AXL, BRAF, CCND1, CCND2, CCND3, CCNE1, CDK2, CDK4, CDK6,
     EGFR, ERBB2, ESR1, FGF19, FGF3, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, IGF1R, KIT, KRAS,
     MDM2, MDM4, MET, MYC, MYCL, MYCN, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PIK3CA,
     PIK3CB, PPARG, RICTOR, TERT

- Gene fusions:
     AKT2, ALK, AR, AXL, BRAF, BRCA1, BRCA2, CDKN2A, EGFR, ERBB2, ERBB4, ERG, ESR1, ETV1,
     ETV4, ETV5, FGFR1, FGFR2, FGFR3, FGR, FLT3, JAK2, KRAS, MDM4, MET, MYB, MYBL1, NF1,
     NOTCH1, NOTCH4, NRG1, NTRK1, NTRK2, NTRK3, NUTM1, PDGFRA, PDGFRB, PIK3CA,
     PPARG, PRKACA, PRKACB, PTEN, RAD51B, RAF1, RB1, RELA, RET, ROS1, RSPO2, RSPO3,
     TERT
 
Methodology:
Next generation sequencing (NGS), Target sequencing
 
AliasesName:
FFPE tissue mutation
 
 
 
Test Code:
092-10-0015

Order Name:
Oncomine Comprehensive Panel (161 Genes) - FFPE

 
Collection Specimen Or Container:
Tissue/ Formalin-fixed paraffin-embedded (FFPE) block
 
Specimen Testing Type:
Tissue, Formalin-fixed paraffin-embedded (FFPE) block,
5 x 10 µm FFPE tissue section, 25 – 300 mm² (≥ 10% Neoplastic cell content)
 
Sub Mission Container:
Tissue/ Formalin-fixed paraffin-embedded (FFPE) block
 
Rejection Criteria:
Neoplastic cell content <10%
 
Specimen Stabillity:
Specimen Type Temperature Time
FFPE Tissue section Ambient temperature 1 month




 
 
 
 
Test Code:
092-10-0015

Order Name:
Oncomine Comprehensive Panel (161 Genes) - FFPE

 
Method detail:
Next generation sequencing (NGS), Target sequencing
 
Turnaround Time:
Reported within 20 days
 
Performing Location:
Research and Development Tel. 14252
 
Specimen Retention Time:
1 month
 
 
 
Test Code:
092-10-0015

Order Name:
Oncomine Comprehensive Panel (161 Genes) - FFPE

 
 
Clinical Information:
Oncomine Comprehensive Panel (161 Genes) contains targeted, multi-biomarker panels that enable simultaneous detection of hundreds of variants across 161 genes relevant to solid tumors. This panel allows concurrent analysis of DNA and RNA to simultaneously detect multiple types of variants, including hotspots, single nucleotide variants (SNVs), insertions and deletions (INDELs), copy number variants (CNVs), and gene fusions to help inform drug discovery research and clinical trial research programs. 
 
Clinical Reference:
https://www.thermofisher.com/order/catalog/product/A35805#/A35805 (Retrieved 27 Jan 2020)