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Test Code:
090-11-0760-01

Order Name:
Natural Killer (NK) Cytotoxicity Activity **

 
Useful For:
To measure the performance of NK cells. Which group of people that should check up “ NK Activity Testing “ as following;
  1. 1. People who have a family history or relatives with cancer.
  2. 2. People who are frequently infected which reflect immune deficiency.
  3. 3. People who have chronic diseases such as liver and kidney diseases, diabetes, and hyperlipidemia.
  4. 4. People who have chronic hepatitis virus infection.
  5. 5. People with ongoing cancer treatment, or who have completed cancer treatment.
  6. 6. People who have little time for rest, a busy life styles, poor health issues, and drink alcohol and smoke.
 
Methodology:
Microfluorometry
 
AliasesName:
Immuno Activity
NK Activity
Natural Cytotoxicity
Percentage of Natural cytotoxic activity
 
 
 
Test Code:
090-11-0760-01

Order Name:
Natural Killer (NK) Cytotoxicity Activity **

 
Collection Specimen Or Container:
Whole Blood/ Special kits
 
Specimen Testing Type:
Heparinized Whole Blood, volume 10 mL
 
Sub Mission Container:
Original tube
 
Rejection Criteria:
Hemolysis: Gross Reject
Lipemia: Gross Reject
Icterus: N/A
Other:
Specimen Over Stability, Clotting, Gross Hemolysis, Gross Lipiemia, Refrigerate or frozen specimen. Inappropiate patient preparation such as some immunosuppressive drug or chemotherapy drug can cause lower result, patient with infection, patient after surgery.
 
Specimen Stabillity:
Specimen Type Temperature Time
Whole blood, Heparinized Room temperature, 18oC to 25oC 12 hours
 
 
 
Test Code:
090-11-0760-01

Order Name:
Natural Killer (NK) Cytotoxicity Activity **

 
Method detail:
Microfluorometry
 
Schedule:
N/A **Sent Out to Wincell Laboratory
 
Turnaround Time:
4 days (official day)
 
Performing Location:
Wincell Laboratory
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
090-11-0760-01

Order Name:
Natural Killer (NK) Cytotoxicity Activity **

 
 
Clinical Information:
Natural killer (NK) cells are large granular lymphocytes that are important effectors of the innate immune system with a critical role in early host defense against invading pathogens and tumor transformed. Circulating NK cells comprise 10–15% of all peripheral blood lymphocytes. Human NK cells are defined phenotypically as their lack of T-cell markers and the expression of CD56 (CD3-/CD56+). NK cells can divide into 2 subset based on the density of their surface expression of CD56. The CD56bright subset, comprising 10 percent of circulating NK cells in peripheral blood, is more proliferative and produces more cytokines e.g. IFN-γ, TNF-α, TNF-β. Whereas, CD56dim subset comprises 90 percent and plays strongly cytotoxicity The functions of NK cells are regulated by the balance between the inhibitory and activating receptors
 
Reference Value:
Male: 43 - 58 %
Female: 35 - 51 %
 
Interpretation:
Natural cytotoxic activity interpretation can be divided as below list;
  • Low level indicates that the effectiveness of the immune cells in respond to tumor or infected cells is low. The causes of reducing natural cytotoxic activity in blood are 1. Patient and/or people who have a family member with cancer e.g. lung cancer, breast cancer, liver cancer, cervical cancer and ovarian cancer. 2. Inappropriate lifestyle e.g. heavy smoking, sleep deprivation or sleep less than 7 hours/day, severe stress and overweight. 3. Malnutrition results from intake diet in the wrong proportion e.g. lacking consume fruits, vegetables or soy proteins. 4. Patient is receiving drugs such as immunosuppressant or chemotherapy. 5. Patient after surgery. 6. Patient who has some disease e.g. perforin deficiency, NEMO mutation.
  • Normal level indicates that your immune cells are in the normal health status.
  • High level indicates that your immune cells look like more active. This level indicates that you may in healthy stage from maximal exercise. However, it may be interpreted as infectious state or have the risk developing to age-related diseases such as Alzheimer’s disease.
 
Clinical Reference:
www.wincellresearch.com/wincell/testing-service.php (Retrieved: 23 May 2019)