Melatonin, Plasma **

Blood/ EDTA Blood (Lavender Top) 3 mL, 2 tubes

Plasma, minimum volume 1 mL x 2 tubes

Plastic tube

Hemolysis
Lipemia
Other reasons for rejection : Polymer gel separation tube (SST or PST)

Plasma EDTA:
- Ambient 14 days
- Refrigerated 30 days
- Frozen 365 days

Melatonin, Plasma **

High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)

N/A **Sent out to MAYO, USA

14-21 days

MAYO, USA (Performing at NMS Labs)
Referral Lab Services, Laboratory Department 14162

Melatonin, Plasma **

Endogenous concentrations of melatonin are of the order of less than 0.02-0.2 ng/mL and vary based on time of day and the patient’s age.  Single oral doses of 10, 20, 40, and 80 mg given to 20 healthy men resulted in mean peak serum concentrations of approximately 4, 9, 17, and 32 ng/mL, respectively, at 1.3 hours post-dose. Up to 240 mg has been safely administered to adults with side effects that include only drowsiness and sleepiness. 

www.mayomedicallaboratories.com (Retrieved: 9 Apr 2025)