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Test Code (รหัสการทดสอบ):
PATHADD09

Order Name (ชื่อการทดสอบ):
MMR (Mismatch Repair), IHC: MLH1, MSH2, MSH6, PMS2

 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
1. Tissue in 10% neutral buffered formalin or 
2. Paraffin embedded tissue block or
3. Unstained positively charged slides as least 4 slides
 
Turnaround Time (ระยะเวลารอผล):
5-7 days
 
Useful For (ประโยชน์การทดสอบ):
Evaluation of tumor tissue to identify patients at risk for having hereditary nonpolyposis colon cancer/Lynch syndrome
 
Methodology (วิธีการทดสอบ):
Immunohistochemistry
 
Test List In Profile (การทดสอบใน Profile):
MLH1, MSH2, MSH6, PMS2
 
AliasesName (ชื่อเรียกอื่นๆ) :
Mismatch Repair Proteins
 
 
 
Test Code (รหัสการทดสอบ):
PATHADD09

Order Name (ชื่อการทดสอบ):
MMR (Mismatch Repair), IHC: MLH1, MSH2, MSH6, PMS2

 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
1. Tissue in 10% neutral buffered formalin or 
2. Paraffin embedded tissue block or
3. Unstained positively charged slides as least 4 slides
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
1. Tissue in 10% neutral buffered formalin or 
2. Paraffin embedded tissue block or
3. Unstained positively charged slides as least 4 slides
 
Sub Mission Container (ภาชนะส่งตรวจ):
1. Tissue in 10% neutral buffered formalin or 
2. Paraffin embedded tissue block or
3. Unstained positively charged slides as least 4 slides
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):
1. Specimens that have been decalcified (all methods)
2. Specimens that have not been formalin-fixed
3. Paraffin-embedded; bone marrow in EDTA
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
 
Specimen Type Temperature
Tissue 1. Room temperature for Tissue in 10% neutral buffered formalin
2. Room temperature for paraffin embedded tissue block and unstained slide
 
 
 
Test Code (รหัสการทดสอบ):
PATHADD09

Order Name (ชื่อการทดสอบ):
MMR (Mismatch Repair), IHC: MLH1, MSH2, MSH6, PMS2

 
Method detail (วิธีการทดสอบ):
Immunohistochemistry
 
Schedule (ตารางการทดสอบ):
Tested daily, at 07:00 am. - 06:00 pm.
 
Turnaround Time (ระยะเวลารอผล):
5-7 days
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Surgical Pathology, Laboratory Department Tel.14146
 
Specimen Retention Time (ระยะเวลาเก็บสิ่งส่งตรวจ):
10 years after final report
 
 
 
Test Code (รหัสการทดสอบ):
PATHADD09

Order Name (ชื่อการทดสอบ):
MMR (Mismatch Repair), IHC: MLH1, MSH2, MSH6, PMS2

 
 
Clinical Information (ข้อมูลทางคลินิก):
A well-defined subtype of colorectal cancer (CRC) is characterized by deficiencies in the mismatch repair (MMR) pathway. MMR status may impact prognosis and benefit of adjuvant chemotherapy. MLH1, MSH2, MSH6, and PMS2 protein expression (as assessed by IHC) and microsatellite instability analysis (MSI) assessed by PCR are well-established tools to screen for Lynch syndrome (LS), and such testing is recommended for all new colorectal cancer diagnoses. MMR IHC and molecular MSI testing also serve as companion diagnostic tests in a wide range of solid tumors for selection of certain immuno-oncology therapies.
 
Clinical Reference (เอกสารอ้างอิง):
1. https://www.mayocliniclabs.com (Retrieved: 1 Feb 2019) 2. https://neogenomics.com/test-menu/mmr-panel-ihc-mlh1-msh2-msh6-pms2 (Retrieved: 29 Jan 2019)