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Test Code:
090-20-2160

Order Name:
Ketone (beta-hydroxybutyrate) (Blood)

 
Useful For:
Monitoring therapy for diabetic ketoacidosis Investigating the differential diagnosis of any patient presenting to the emergency room with hypoglycemia, acidosis, suspected alcohol ingestion, or an unexplained increase in the anion gap In pediatric patients, the presence or absence of ketonemia/uria is an essential component in the differential diagnosis of inborn errors of metabolism
 
Methodology:
Biosenser Technology
 
AliasesName:
B-hydroxybutyrate, Serum
Beta-Hydroxy Butyric Acid, Serum
Blood Ketone, Serum
Hydroxybutyrate, Beta, Serum
Ketone Bodies, Serum
 
 
 
 
Test Code:
090-20-2160

Order Name:
Ketone (beta-hydroxybutyrate) (Blood)

 
Collection Specimen Or Container:
Blood/ K3 EDTA (Lavender Top) 3 mL, 1 tube
 
Specimen Testing Type:
Whole Blood EDTA, minimum volume 3 mL
 
Sub Mission Container:
Plastic vial
 
Specimen Stabillity:
K3EDTA Whole bloood (keep in original tube) - within 30 minutes after blood collection.
 
 
 
Test Code:
090-20-2160

Order Name:
Ketone (beta-hydroxybutyrate) (Blood)

 
Method detail:
Biosenser Technology
 
Schedule:
Tested daily (24 hours)
 
Turnaround Time:
Collected specimen to report within 1.5 hours (90 mins)
 
Performing Location:
Chemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
090-20-2160

Order Name:
Ketone (beta-hydroxybutyrate) (Blood)

 
 
Clinical Information:
Beta-hydroxybutyrate (BHB) is 1 of 3 sources of ketone bodies. Its relative proportion in the blood (78%) is greater than the other 2 ketone bodies, acetoacetate (20%) and acetone (2%). During carbohydrate deprivation (starvation, digestive disturbances, frequent vomiting), decreased carbohydrate utilization (diabetes mellitus), glycogen storage diseases, and alkalosis, acetoacetate production increases. The increase may exceed the metabolic capacity of the peripheral tissues. As acetoacetate accumulates in the blood, a small amount is converted to acetone by spontaneous decarboxylation. The remaining and greater portion of acetoacetate is converted to BHB.
 
Reference Value:
< 0.6 mmol/L
 
Interpretation:
The beta-hydroxybutyrate (BHB)/acetoacetate ratio is typically between 3:1 and 7:1 in severe ketotic states. BHB increases in response to asting, but should not exceed 0.4 mmol/L following an overnight fast (up to 12 hours). In pediatric patients, a hypo- or hyper-ketotic state (with or without hypoglycemia) may suggest specific groups of metabolic disorders.
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, FreeStyle OptiumH Beta-Ketone, Abbott Diabetes Care Ltd., Range road, Witney, Oxon OX29 0YL, UK, 2013-2015 Abbott ART30968-001 Rev.A 07/15.
  2. http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)