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Test Code:
PATHADD08

Order Name:
Immunohistochemical stain: P53

 
Useful For:
Aids in the identification of neoplastic cells
 
Methodology:
Immunohistochemistry
 
 
 
Test Code:
PATHADD08

Order Name:
Immunohistochemical stain: P53

 
Collection Specimen Or Container:
1. Tissue in 10% neutral buffered formalin or 
2. Paraffin embedded tissue block or
3. Unstained positively charged slides as least 2 slides
 
Specimen Testing Type:
1. Tissue in 10% neutral buffered formalin or 
2. Paraffin embedded tissue block or
3. Unstained positively charged slides as least 2 slides
 
Sub Mission Container:
1. Tissue in 10% neutral buffered formalin or 
2. Paraffin embedded tissue block or
3. Unstained positively charged slides as least 2 slides
 
Rejection Criteria:
1. Wet/ frozen tissue Cytology smears 
2. Non formalin fixed tissue 
3. Non paraffin embedded tissue 
4. Non charged slides
 
Specimen Stabillity:
 
Specimen Type Temperature
Tissue 1. Room temperature for Tissue in 10% neutral buffered formalin
2. Room temperature for paraffin embedded tissue block and unstained slide
(Breast tissue should be fixed in formalin for 6-48 hours, not to exceed 72 hours)
 
 
 
Test Code:
PATHADD08

Order Name:
Immunohistochemical stain: P53

 
Method detail:
Immunohistochemistry
 
Schedule:
Tested daily, at 07:00 am. - 06:00 pm.
 
Turnaround Time:
5-7 days
 
Performing Location:
Surgical Pathology, Laboratory Department Tel.14146
 
Specimen Retention Time:
10 years after final report
 
 
 
Test Code:
PATHADD08

Order Name:
Immunohistochemical stain: P53

 
 
Clinical Information:
p53 is a tumor-suppressor protein. Genetic events (mutation and deletion) that affect both P53 alleles can lead to loss of cell cycle control in the setting of DNA damage, resulting in genetic instability and neoplastic transformation. Mutated p53 also has a prolonged half-life compared to wild-type p53 and, thus, accumulates in the nucleus and can be detected by immunohistochemistry. Abnormalities of the P53 gene are one of the most common genetic changes associated with cancer and can be found in a wide variety of tumor types, where they are generally associated with a worse prognosis. The p53 protein can be readily detected in a subset of cancers of the colon, stomach, bladder, breast, lung, and testes and in melanoma and lymphoma.
 
Clinical Reference:
https://www.mayocliniclabs.com (Retrieved: 29 Jan 2019)