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Test Code:
IAGM

Order Name:
Immunoglobulin level (IgA,IgG,IgM)

 
Useful For:
Detecting or monitoring of monoclonal gammopathies and immune deficiencies
 
Methodology:
Immunoturbidimetric
 
Test List In Profile:
Immunoglobulin A (IgA)
Immunoglobulin G (IgG)
Immunoglobulin M (IgM)
 
AliasesName:
Immunoglobulin A (IgA)
Immunoglobulin G (IgG)
Immunoglobulin M (IgM)
 
 
 
Test Code:
IAGM

Order Name:
Immunoglobulin level (IgA,IgG,IgM)

 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 1 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: 3+ or above reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Refrigerated, 2oC to 8oC 4 months
Frozen, -20o 6 months
 
 
 
Test Code:
IAGM

Order Name:
Immunoglobulin level (IgA,IgG,IgM)

 
Method detail:
Immunoturbidimetric
 
Schedule:
Tested daily (24 hours)
 
Turnaround Time:
Collected specimen to report within 1.5 hours (90 mins)
 
Performing Location:
Chemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
IAGM

Order Name:
Immunoglobulin level (IgA,IgG,IgM)

 
 
Clinical Information:
The gamma globulin band as seen in conventional serum protein electrophoresis consists of 5 immunoglobulins. In normal serum, about 80% is immunoglobulin G (IgG), 15% is immunoglobulin A (IgA), 5% is immunoglobulin M (IgM), 0.2% is immunoglobulin D (IgD), and a trace is immunoglobulin E (IgE). Elevations of IgG, IgA, and IgM may be due to polyclonal immunoglobulin production. Monoclonal gammopathies of all types may lead to a spike in the gamma globulin zone seen on serum protein electrophoresis. Monoclonal elevations of IgG, IgA, IgD, and IgE characterize multiple myeloma. Monoclonal elevations of IgM occur in macroglobulinemia. Decreased immunoglobulin levels are found in patients with congenital deficiencies.
 
Interpretation:
Increased serum immunoglobulin concentrations occur due to polyclonal or oligoclonal immunoglobulin proliferation in hepatic disease (hepatitis, liver cirrhosis), connective tissue diseases, acute and chronic infections, as well as in the cord blood of neonates with intrauterine and perinatal infections. Elevations of immunoglobulin G (IgG), immunoglobulin A (IgA), or immunoglobulin M (IgM) may occur in monoclonal gammopathies such as multiple myeloma (IgG, IgA), macroglobulinemia (IgM), primary systemic amyloidosis, monoclonal gammopathy of undetermined significance, and related disorders. Decreased levels are found in patients with primary or secondary immune deficiencies.
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, Architect® IgA, Abbott Laboratories, Abbott Park IL 60064 USA, January 2016.
  2. Manufacturer’s reagent package insert, Architect® IgG, Abbott Laboratories, Abbott Park IL 60064 USA, November 2015.
  3. Manufacturer’s reagent package insert, Architect® IgM, Abbott Laboratories, Abbott Park IL 60064 USA, October 2015.
  4. http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)