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Test Code:
090-71-5525

Order Name:
INVITAE Cardio screen (Proactive test) **

 
Useful For:
Determine a healthy adult's predisposition to cardiovascular conditions.

If you checked "No" to all questions, your patient is likely a good candidate for Proactive genetic testing. If you checked "Yes" for any of the boxes above, you may want to consider further evaluation to determine whether Diagnostic testing is more appropriate for your patient.

Do any of the following apply to your patient or their close blood relative* ?
  • Diagnosis of a potentially hereditary cardiovascular condition such as cardiomyopathy2, arrhythmia3, aortopathy4, familial hypercholesterolemia, pulmonary arterial hypertension, or hereditary hemorrhagic telangiectasia
  • Early-onset cardiovascular disease:
    • ICD/Pacemaker (younger than age 50)
    • Heart failure or heart transplant (younger than age 60)
    • Early "heart attack", coronary artery disease, or stroke (males younger than age 55; females younger than age 65)
    • Aortic aneurysm/dissection (younger than age 50)
  • Untreated LDL ≥190
  • Unexplained cardiac arrest(s) or sudden death, or sudden infant death syndrome (SIDS)
  • Unexplained syncope or syncope with exercise or emotional distress
*Close blood relatives include sibling, half-sibling, parent, child, aunt/uncle, niece/nephew, grandparent, or grandchild
 
Methodology:
Next-generation sequencing (NGS)
 
Test List In Profile:
ACTA2 ACTC1 ACTN2 ACVRL1 APOB BAG3 BMPR2 CACNA1C CACNB2 CALM1 CALM2 CALM3 CASQ2 CAV1 CAV3 COL3A1 CRYAB CSRP3 DES DMD DSC2 DSG2 DSP EMD ENG F2 F5 F9 FBN1 FHL1 FLNC GDF2 GLA GPD1L HCN4 JUP KCNE1 KCNE2 KCNH2 KCNJ2 KCNQ1 LAMP2 LDLR LDLRAP1 LMNA MYBPC3 MYH11 MYH7 MYL2 MYL3 MYLK NKX25 PCSK9 PKP2 PLN PRKAG2 PRKG1 PROC PROS1 RBM20 RYR2 SCN5A SERPINC1 SGCD SMAD3 SMAD4 TCAP TGFB2 TGFB3 TGFBR1 TGFBR2 TMEM43 TNNC1 TNNI3 TNNT2 TPM1 VCL
 
 
 
Test Code:
090-71-5525

Order Name:
INVITAE Cardio screen (Proactive test) **

 
Patient Preparation:
Genetics Counseling
​ไม่ทำการตรวจ Proactive ในผู้ที่อายุต่ำกว่า 18 ปี 
 
Collection Specimen Or Container:
Blood/ K3 EDTA (Lavender Top) 3 mL, 2 tubes

Document Require:
Completed Invitae Proactive Screen - Requesition & Consent Form
 
Specimen Testing Type:
Blood/ K3 EDTA (Lavender Top) 3 mL, 2 tubes
 
Sub Mission Container:
Whole blood EDTA, minimum volume 6 mL
 
Rejection Criteria:
  • Hemolyzed or clotted blood
  • Blood (or saliva) from patients who have had an allogeneic (non-self donor) bone marrow transplant
  • Blood (or saliva) from patients who have had an allogeneic (non-self donor) stem cell transplant
  • Blood (or saliva) from patients who had a blood transfusion less than two weeks prior to specimen collection
 
Specimen Stabillity:
Specimen Type Temperature Time
Whole blood EDTA Refrigerated, 2oC to 8oC 14 days
Saliva (2mL) in special collection kit * Ambient 30 days
* Optional, Nurse can request the special collection kit from Lab 4th Floor, Tel. 14160-2​
** Sending to USA
 
 
 
 
Test Code:
090-71-5525

Order Name:
INVITAE Cardio screen (Proactive test) **

 
Method detail:
Next-generation sequencing (NGS)
 
Schedule:
N/A **Sent out to Precision Health (INVITAE, USA)
 
Turnaround Time:
20-25 days
 
Performing Location:
Precision Health (INVITAE, USA)
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
090-71-5525

Order Name:
INVITAE Cardio screen (Proactive test) **

 
 
Clinical Information:

The Invitae Cardio Screen analyzes more than 75 genes related to inherited cardiovascular conditions that, if detected early, may have effective medical interventions and preventive measures. Conditions tested include aortopathies, arrhythmias, cardiomyopathies, thrombophilia, and genetic forms of high blood pressure and high cholesterol.

All genes included in the Invitae Cardio Screen can also be found in the Invitae Genetic Health Screen, which includes cardiovascular and cancer genes, as well as several additional medically actionable conditions.

 
Reference Value:
An interpretive report will be provided.
 
Interpretation:
Report integrate relevant guidelines to help develop a personalized screening and prevention plan for patients.
 
Clinical Reference:
www.invitae.com (Retrieved: 29 Jun 2020)