bih.button.backtotop.text
BROWSE BY TEST NAME
%
1
2
3
5
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Clear
 
Test Code:
090-10-0440-01

Order Name:
Heterophile Antibody

 
Useful For:
A Rapid latex agglutination test for use with human serum or EDTA plasma in the detection and semi-quantitative measurement of the heterophile antibody associated with infectious mononucleosis (IM).Infectious mononucleosis (IM) involves the reticuloendothelial tissue and is believed to be caused by the Epstein Barr (EB) virus.
 
Methodology:
Latex slide Agglutination
 
AliasesName:
E. B. Virus (Early Antigen)
EA (Early Antigen)
Early Antigen EBV
EARLY AG(S) Epstein Barr Virus
Early Ag Ab Epstein-Barr Virus (EBV)
Early Antigen Monospot Test Infectious Mononucleosis
 
 
 
Test Code:
090-10-0440-01

Order Name:
Heterophile Antibody

 
Collection Specimen Or Container:
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 1 mL
 
Sub Mission Container:
Plastic tube
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Refrigerated, 2oC to 8oC 48 hours
 
 
 
Test Code:
090-10-0440-01

Order Name:
Heterophile Antibody

 
Method detail:
Latex slide Agglutination
 
Schedule:
Tested Daily (24 hours)
 
Turnaround Time:
Collected specimen to reported within 90 mins.
 
Performing Location:
Hematology, Laboratory Department, Tel. 17254
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
090-10-0440-01

Order Name:
Heterophile Antibody

 
 
Clinical Information:
Epstein-Barr virus (EBV), a member of the herpesvirus group, is the etiologic agent of infectious mononucleosis. EBV infections are difficult to diagnose in the laboratory since the virus does not grow in standard cell cultures. The majority of infections can be recognized, however, by testing the patient's serum for heterophile antibodies (rapid latex slide agglutination test; eg, MONOS / Infectious Mononucleosis Rapid Test, Serum). Heterophile antibodies usually appear within the first 3 weeks of illness, but then decline rapidly within a few weeks. The heterophile antibody, however, fails to develop in about 10% of adults, more frequently in children, and almost uniformly in infants with primary EBV infections. Most of these heterophile antibody negative cases of infectious mononucleosis-like infections are due to cytomegalovirus, but in 1 series of 43 cases, EBV was the cause in 7. In cases where EBV is suspected but the heterophile antibody is not detected, an evaluation of EBV-specific antibodies (eg, IgM and IgG antibodies to EBV viral capsid antigen: VCA) and antibodies to EBV nuclear antigen (EBNA) may be useful. The EBV EIA tests that detect antibodies to the EBV VCA and early antigen (EA) are more sensitive than heterophile antibody tests.
 
Reference Value:
Negative
 
Interpretation:
The presence of antibody to the early antigen (EA) of Epstein-Barr virus (EBV) indicates that EBV is actively replicating.Generally, this antibody can only be detected during active EBV infection, such as in patients with infectious mononucleosis. Clinical studies have indicated that patients who have chronic active or reactivated EBV infection commonly have elevated levels of IgG-class antibodies to the EA of EBV.
 
Clinical Reference:
  1. Manufacturer’s reagent Package insert AVITEX IM Omega Diagnostics Limited United Kingdom.
  2. http://www.mayomedicallaboratories.com (Retrieved: 22 Jan 2019)