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Test Code:
HBOP

Order Name:
Hemoglobin Typing

 
Useful For:
Diagnosis and comprehensive classification of thalassemias 
 
Methodology:
Capillary Electrophoresis (CE)
 
AliasesName:
Hemoglobin Electrophoresis
 
 
 
Test Code:
HBOP

Order Name:
Hemoglobin Typing

 
Collection Specimen Or Container:
Blood/ K3 EDTA (K3E) (Lavender Top) 3 mL, 1 tube
 
Specimen Testing Type:
Blood, minimum volume 0.5 mL
 
Sub Mission Container:
Original tube
 
Specimen Stabillity:
Specimen Type Temperature Time
Whole blood, EDTA Refrigerated, 2oC to 8oC 2 days
 
 
 
Test Code:
HBOP

Order Name:
Hemoglobin Typing

 
Method detail:
Capillary Electrophoresis (CE)
 
Schedule:
Tested Daily (24 hours)
 
Turnaround Time:
Received specimen to report within 1 day
 
Performing Location:
Hematology, Laboratory Department Tel. 17254
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
HBOP

Order Name:
Hemoglobin Typing

 
 
Clinical Information:
This consultative study has the ability to test for the detection of almost all known hemoglobin disorders in an economical manner. Because this can include multiple tests for alpha-thalassemias, beta-thalassemias, delta-beta-thalassemia, hereditary persistence of fetal hemoglobin (HPFH) and for all known Hb variants, an expert in these disorders can guide testing to explain the clinical question or CBC values. This evaluation is particularly useful for complete classification of compound combinations of Hb S with alpha- or beta-thalassemia, Hb E/beta-0-thalassemia, and many other complex thalassemic disorders. Since iron deficiency can mimic thalassemias, ferritin levels are measured to evaluate this possibility. The thalassemias are a group of disorders of hemoglobin (Hb) synthesis. Normal adult Hb consists of 2 alpha globin chains (encoded by 2 pairs of alpha globin genes, each pair located on chromosome 16), and 2 beta globin chains (encoded by 2 beta globin genes, each located on chromosome 11). Thalassemia syndromes result from an underproduction of 1 or 2 types of globin chains and are characterized by the type (alpha, beta, delta) and magnitude of underproduction (number of defective genes) and the severity of clinical symptoms (minor, intermedia, major). The severity of the clinical and hematologic effects is directly related to the imbalance of alpha-like to beta-like chains. The most common form of thalassemia is alpha thalassemia. Hemoglobin H (Hb H) disease, results from dysfunction of 3 alpha chains, and shows a variable phenotype with most showing moderate anemia.
 
Clinical Reference:
http://www.mayomedicallaboratories.com (Retrieved: 22 Jan 2019)