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Test Code:
090-71-5080-01

Order Name:
HLA-B 5801 - Please use order Pharmacogenomics in HLA-B **

 
Useful For:
Genotyping for HLA-B*58:01 before allopurinol therapy
 
Methodology:
Polymerase chain reaction
 
AliasesName:
Pharmacogenetic for HLA-B*58:01
Allopurinol Hypersensitivity Syndrome (AHS)
Lesch-Nyhan Syndrome
Gout
Stevens-Johnson Syndrome
Toxic Epidermal Necrolysis
Urate Kidney Stones
 
 
 
Test Code:
090-71-5080-01

Order Name:
HLA-B 5801 - Please use order Pharmacogenomics in HLA-B **

 
Collection Specimen Or Container:
Blood/ K3 EDTA (Lavender Top) 3 mL, 2 tubes
 
Specimen Testing Type:
Whole Blood EDTA, minimum volume 3 mL
 
Sub Mission Container:
Original tube
 
Rejection Criteria:
Hemolysis: Hemolysis interfere
Other: Over Stability will be reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Whole blood, EDTA Ambient (preferred) Same day
Refrigerated, 2oC to 8oC 7 days
 
 
 
Test Code:
090-71-5080-01

Order Name:
HLA-B 5801 - Please use order Pharmacogenomics in HLA-B **

 
Method detail:
Polymerase chain reaction
 
Schedule:
N/A **Sent Out to Ramathibodi
 
Turnaround Time:
Reported within 3-5 days (exception for official holidays)
 
Performing Location:
Ramathibodi
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
090-71-5080-01

Order Name:
HLA-B 5801 - Please use order Pharmacogenomics in HLA-B **

 
 
Clinical Information:
Guidelines from the Clinical Pharmacogenomics Implementation Consortium (CPIC) recommend HLA-B*58:01 genotyping be performed when considering prescribing allopurinol, and that allopurinol should not be prescribed to patients who test positive for the allele due to the increased risk of SCAR.(1) In addition, guidelines developed by the 2012 American College of Rheumatology for Management of Gout recommend that HLA-B*58:01 testing should be considered in select patient subpopulations at an elevated risk for allopurinol-induced SCAR. Those of Korean descent, especially those with stage 3 or higher chronic kidney disease, or of Han Chinese or Thai descent, irrespective of renal function, should be tested.(2)
 
Reference Value:
Negative
 
Interpretation:
Positivity for HLA-B*58:01 confers increased risk for hypersensitivity to allopurinol.
 
Clinical Reference:
  1. www.si.mahidol.ac.th (Retrieved: 18 Jan 2019)
  2. www.mayomedicallaboratories.com (Retrieved: 18 Jan 2019)