Test Code (รหัสการทดสอบ):
Order Name (ชื่อการทดสอบ):
Clinical Information (ข้อมูลทางคลินิก):
Gentamicin is used in the treatment of serious infections involving aminoglycoside-sensitive organisms. Monitoring gentamicin concentration in serum or plasma, along with careful clinical assessment, is the most effective means of ensuring adequate therapy. Gentamicin concentration correlates better with antibacterial activity than dosage. A standard dose of gentamicin does not always yield a predictable concentration because the drug’s concentration also depends on the patient’s volume of distribution and on the drug elimination. These factors are influenced by the mode of administration, the volume of extracellular fluid, renal retention, and physiological changes during therapy. Gentamicin has a narrow range of safe and effective concentration. Exposure to high concentrations for a prolonged period may cause renal impairment or ototoxicity. Patients with impaired renal function should be monitored closely while on gentamicin therapy because nephrotoxicity caused by gentamicin may be difficult to distinguish from symptoms of underlying renal disease.
Reference Value (ค่าอ้างอิง):
Peak level: 3 – 10 µg/mL
Trough level: < 2 µg/mL
Note: The susceptibility of the infecting organism, the severity of the infection, and the general health of the patient should be considered when determining an adequate drug level for individual patients.
Periodic measurements of both peak and trough concentrations of gentamicin are recommended to ensure adequate drug levels and prevent toxic side effects. The susceptibility of the infecting organism, the severity of the infection, and the general health of the patient should be considered when determining an adequate drug level for individual patients.
Clinical Reference (เอกสารอ้างอิง):
- Manufacturer’s reagent package insert, Architect® Gentamicin, Microgenics Corporation 46500 Kato Road Fremont, CA 94538 USA .
- Reference of reference intervals: UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com (Retrieved: July 2018)
- http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)