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Clear
 
Test Code:
090-30-1410-01

Order Name:
Gentamicin

 
Useful For:
The results obtained are used in the diagnosis and treatment of gentamicin overdose and in monitoring levels of gentamicin to help ensure appropriate therapy.
 
Methodology:
Particle-enhanced turbidimetric inhibition immunoassay (PETINIA)
 
 
 
Test Code:
090-30-1410-01

Order Name:
Gentamicin

 
Patient Preparation:
Follow the instruction of physician and pharmarcist.
 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 0.5 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: 4+ reject
Lipemia: 4+ reject
Icterus: 4+ reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Refrigerated, 2oC to 8oC 7 days
Frozen, -20oC 14 days
 
 
 
Test Code:
090-30-1410-01

Order Name:
Gentamicin

 
Method detail:
Particle-enhanced turbidimetric inhibition immunoassay (PETINIA)
 
Schedule:
Tested daily (24 hours)
 
Turnaround Time:
Collected specimen to report within 1.5 hours (90 mins)
 
Performing Location:
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
090-30-1410-01

Order Name:
Gentamicin

 
 
Clinical Information:
Gentamicin is used in the treatment of serious infections involving aminoglycoside-sensitive organisms. Monitoring gentamicin concentration in serum or plasma, along with careful clinical assessment, is the most effective means of ensuring adequate therapy. Gentamicin concentration correlates better with antibacterial activity than dosage. A standard dose of gentamicin does not always yield a predictable concentration because the drug’s concentration also depends on the patient’s volume of distribution and on the drug elimination. These factors are influenced by the mode of administration, the volume of extracellular fluid, renal retention, and physiological changes during therapy. Gentamicin has a narrow range of safe and effective concentration. Exposure to high concentrations for a prolonged period may cause renal impairment or ototoxicity. Patients with impaired renal function should be monitored closely while on gentamicin therapy because nephrotoxicity caused by gentamicin may be difficult to distinguish from symptoms of underlying renal disease.
 
Reference Value:
Peak level: 3 – 10 µg/mL
Trough level: < 2 µg/mL

Note: The susceptibility of the infecting organism, the severity of the infection, and the general health of the patient should be considered when determining an adequate drug level for individual patients.
 
Interpretation:
Periodic measurements of both peak and trough concentrations of gentamicin are recommended to ensure adequate drug levels and prevent toxic side effects. The susceptibility of the infecting organism, the severity of the infection, and the general health of the patient should be considered when determining an adequate drug level for individual patients.
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, Architect® Gentamicin, Microgenics Corporation 46500 Kato Road Fremont, CA 94538 USA, October 2016
  2. Reference of reference intervals: UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com (Retrieved: July 2018)
  3. http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)