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Test Code:
FOL

Order Name:
Folic Acid*

 
Useful For:
Determination of folate in human serum
 
Methodology:
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
AliasesName:
Folate 
 
 
 
Test Code:
FOL

Order Name:
Folic Acid*

 
Collection Specimen Or Container:
Blood/ Plain Blood 6 mL (Red Top) 1 tube
 
Specimen Testing Type:
Serum, minimum volume 1 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: Mild or above reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum (keep in original tube) Refrigerated, 2oC to 8oC 8 hours
Serum Refrigerated, 2oC to 8oC 7 days
Frozen, -20oC 30 days
 
 
 
Test Code:
FOL

Order Name:
Folic Acid*

 
Method detail:
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
Schedule:
Tested daily (24 hours)
 
Turnaround Time:
Specimen collected to reported within 2:00 hours (120 mins)
 
Performing Location:
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
FOL

Order Name:
Folic Acid*

 
 
Clinical Information:
Folates are a class of vitamin compounds related to pteroylglutamic acid (PGA), which serve as cofactors in the enzymatic transfer of single carbon units in a variety of metabolic pathways. Folate mediated one-carbon
metabolism represents one of the most important biochemical reactions that occur in cells. Folates are necessary for nucleic acid and mitochondrial protein synthesis, amino acid metabolism, and other cellular processes that involve single carbon transfers. Folates can serve as carbon donors or acceptors. Since different metabolic pathways require carbon groups with different levels of oxidation, cells contain numerous enzymes that change the oxidation state of carbon groups carried by folates  resulting in different metabolically active forms of folate. The predominant form of circulating folate is 5-methyltetrahydrofolic acid (5-mTHF). A methyl
group is transferred from 5-mTHF to cobalamin in the pathway that links metabolism of folic acid and vitamin B12. 

Folate deficiency can be caused by low dietary intake, malabsorption due to gastrointestinal diseases, inadequate utilization due to enzyme deficiencies or folate antagonist therapy, drugs such as alcohol and
oral contraceptives, and excessive folate demand, such as during pregnancy. Because deficiencies of both vitamin B12 and folate can lead to megaloblastic (macrocytic) anemia, appropriate treatment requires
differential diagnosis of the deficiency; thus, both vitamin B12 and folate values are needed. Low serum folate levels reflect the first stage of negative folate balance, and precede tissue depletion.  Low red-blood-cell folate values reflect the second stage of negative folate balance, and more closely correlate with tissue levels and megaloblastic anemia.
 
Reference Value:
3.1- 20.5 ng/mL 
 
Clinical Reference:
Manufacturer’s Reagent package insert Architect Folate, November 2015, Abbott Ireland, Diagnostics Division Lisnamuck Longford Co., Ireland.