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Test Code (รหัสการทดสอบ):
090-70-2511

Order Name (ชื่อการทดสอบ):
Factor II Gene Mutation & Factor V Leiden

 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ K3 EDTA (Lavender Top) 3 mL, 1 tube
 
Turnaround Time (ระยะเวลารอผล):
Received specimen to reported within 1 day.
 
Useful For (ประโยชน์การทดสอบ):
This test is intended to provide results for Factor II (G20210A) and Factor V Leiden (G1691A) mutations as an aid in the diagnosis in individuals with suspected thrombophilia.
 
Methodology (วิธีการทดสอบ):
Multiplex real-time polymerase chain reaction (PCR)
 
Test List In Profile (การทดสอบใน Profile):
Factor II Gene Mutation 
Factor V Leiden 
 
AliasesName (ชื่อเรียกอื่นๆ) :
Prothrombin G20210A Mutation
Factor II 20210 mutation
Prothrombin 20210 mutation
Factor V Leiden (R506Q) Mutation
Activated protein C (APC) resistance mutation 
FVL R506Q mutation 
 
 
 
Test Code (รหัสการทดสอบ):
090-70-2511

Order Name (ชื่อการทดสอบ):
Factor II Gene Mutation & Factor V Leiden

 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ K3 EDTA (Lavender Top) 3 mL, 1 tube
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Whole blood, minimum volume 0.5 mL
 
Sub Mission Container (ภาชนะส่งตรวจ):
Plastic tube
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):
Hemolysis: N/A
Lipemia: N/A
Icterus: N/A
Other :
  1. Heparin, anticoagulant blood
  2. Whole blood is stored at room temperature longer than 24 hr.
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
Specimen Type Temperature Time
Whole blood, EDTA Room temperature, 22oC to 28oC 24 hours
Refrigerated, 2oC to 8oC 15 days
Frozen, -20oC to -80oC 3 months
 
 
 
Test Code (รหัสการทดสอบ):
090-70-2511

Order Name (ชื่อการทดสอบ):
Factor II Gene Mutation & Factor V Leiden

 
Method detail (วิธีการทดสอบ):
Multiplex real-time polymerase chain reaction (PCR)
 
Schedule (ตารางการทดสอบ):
Test daily
 
Turnaround Time (ระยะเวลารอผล):
Received specimen to reported within 1 day.
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Molecular biology & Genetics, Laboratory Department Tel.14168
 
Specimen Retention Time (ระยะเวลาเก็บสิ่งส่งตรวจ):
7 days
 
 
 
Test Code (รหัสการทดสอบ):
090-70-2511

Order Name (ชื่อการทดสอบ):
Factor II Gene Mutation & Factor V Leiden

 
 
Clinical Information (ข้อมูลทางคลินิก):
The association of Factor II (G20210A) and Factor V Leiden (G1691A) mutations with an increased risk for venous thrombosis has been well documented. The Factor II or Prothrombin (G20210A) mutation refers to the G to A transition at nucleotide 20210 in the 3' untranslated region of the gene and is associated with increased plasma levels of prothrombin. Factor V Leiden (G1691A) refers to the G to A transition at nucleotide position 1691 of the Factor V gene, resulting in the substitution of the amino acid arginine by glutamine in the Factor V protein, causing resistance to cleavage by Activated Protein C (APC). Factor II (G20210A) and Factor V Leiden (G1691A) mutations are present in 2% and 5% of the general population, respectively.
 
Reference Value (ค่าอ้างอิง):
Test Reference Value
Factor II Gene Mutation No Mutation of the G20210A prothrombin gene 
Factor V Leiden No Mutation of the G1691A factor V gene
 
Interpretation (การแปลผล):
  1. The results ot the test assay should be interpreted in conjunction with other laboratory and clinical data available to the clinician.
  2. Rare Factor V mutations (A1696G, G1689A, and A1692C) and any additional SNPs in the probe binding region may interfere with the target detection and yield an INVALID result.
 
Clinical Reference (เอกสารอ้างอิง):
Manufacturer’s packages insert, Xpert® Factor II & Factor V Assay, August 2017, Cepheid, CA 94089 Sunnyvale, USA.