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Test Code:
090-31-1901

Order Name:
E1 (Estrone), Serum **

 
Useful For:

As part of the diagnosis and workup of precocious and delayed puberty in females and, to a lesser degree, males

As part of the diagnosis and workup of suspected disorders of sex steroid metabolism (eg, aromatase deficiency and 17 alpha-hydroxylase deficiency)

As an adjunct to clinical assessment, imaging studies and bone mineral density measurement in the fracture risk assessment of postmenopausal women, and, to a lesser degree, older men

Monitoring low-dose female hormone replacement therapy in postmenopausal women

Monitoring antiestrogen therapy (eg, aromatase inhibitor therapy)

 
Methodology:
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
 
 
 
Test Code:
090-31-1901

Order Name:
E1 (Estrone), Serum **

 
Patient Preparation:
N/A
 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 2 mL 
(Centrifuge and remove serum from red blood cells within 2 hours of draw)
 
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Hemolysis: Gross OK
Lipemia: Gross OK
Icterus: Gross OK
Other: Serum gel or SST tube reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Ambient 28 days
Refrigerated, 2oC to 8oC (preferred) 28 days
Frozen 28 days
 
 
 
Test Code:
090-31-1901

Order Name:
E1 (Estrone), Serum **

 
Method detail:
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
 
Schedule:
N/A **Sent out to MAYO, USA
 
Turnaround Time:
Received specimen to report within 14 days
 
Performing Location:
MAYO Laboratory
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
090-31-1901

Order Name:
E1 (Estrone), Serum **

 
 
Clinical Information:
Estrogens are involved in development and maintenance of the female phenotype, germ cell maturation, and pregnancy. They also are important for many other, nongender-specific processes, including growth, nervous system maturation, bone metabolism/remodeling, and endothelial responsiveness. The 2 major biologically active estrogens in nonpregnant humans are estrone (E1) and estradiol (E2). A third bioactive estrogen, estriol (E3), is the main pregnancy estrogen, but plays no significant role in nonpregnant women or men.

E2 is produced primarily in ovaries and testes by aromatization of testosterone. Small amounts are produced in the adrenal glands and some peripheral tissues, most notably fat. By contrast, most of the circulating E1 is derived from peripheral aromatization of androstenedione (mainly adrenal). E2 and E1 can be converted into each other, and both can be inactivated via hydroxylation and conjugation. E2 demonstrates 1.25-5 times the biological potency of E1. E2 circulates at 1.5-4 times the concentration of E1 in premenopausal, nonpregnant women. E2 levels in men and postmenopausal women are much lower than in nonpregnant women, while E1 levels differ less, resulting in a reversal of the premenopausal E2:E1 ratio. E2 levels in premenopausal women fluctuate during the menstrual cycle. They are lowest during the early follicular phase. E2 levels then rise gradually until 2 to 3 days before ovulation, at which stage they start to increase much more rapidly and peak just before the ovulation-inducing luteinizing hormone/follicle stimulating hormone surge at 5 to 10 times the early follicular levels. This is followed by a modest decline during the ovulatory phase. E2 levels then increase again gradually until the midpoint of the luteal phase and thereafter decline to trough, early follicular levels.
 
Reference Value:
Provide in report, the reference range depends on Sex and Tanner stage (age).
 
Clinical Reference:
www.mayomedicallaboratories.com (Retrieved: 2 Dec 2020)