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Test Code:
DD

Order Name:
D-Dimer

 
Useful For:
Diagnosis of intravascular coagulation and fibrinolysis, also known as disseminated intravascular coagulation (DIC), acute pulmonary embolism or deep vein thrombosis especially when combined with clinical information and other laboratory test data (eg, platelet count, assays of clottable fibrinogen and soluble fibrin monomer complex, and clotting time assays-prothrombin time and activated partial thromboplastin time)
 
Methodology:
Immunoturbidimetric
 
 
 
Test Code:
DD

Order Name:
D-Dimer

 
Collection Specimen Or Container:
Blood/ Sodium citrate tube (Sodium Citrate 3.2% anticoagulant, Blue top) 3 mL, 1 tube
 
Specimen Testing Type:
Citrate plasma, minimum volume 0.5 mL
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Hemolysis: Hemoglobin >500 mg/dL will be reject.
Lipemia: Triglyceride >1,327 mg/dL will be reject.
Icterus: Bilirubin >18 mg/dL will be reject.
Other:
  1. Clotted specimen will be rejected.
  2. Rheumatoid factor >1,400 IU/mL will be reject.
 
Specimen Stabillity:
Specimen type Temperature Time
Whole blood, Sodium citrate Room temperature, 18oC to 25oC 4 hours
Plasma, Sodium citrate Refrigerated, 2oC to 8oC 4 hours
Room temperature, 18oC to 25oC 4 hours
Frozen, -20oC 2 weeks
Frozen, -70oC 1 year
 
 
 
Test Code:
DD

Order Name:
D-Dimer

 
Method detail:
Immunoturbidimetric
 
Schedule:
Tested Daily (24 hours)
 
Turnaround Time:
Collected specimen to report within 90 mins.
 
Performing Location:
Hematology, Laboratory Department Tel. 17254
 
Specimen Retention Time:
14 days
 
 
 
Test Code:
DD

Order Name:
D-Dimer

 
 
Clinical Information:
The specific degradation of fibrin (ie, fibrinolysis) is the reactive mechanism responding to the formation of fibrin. Plasmin is the fibrinolytic enzyme derived from inactive plasminogen. Plasminogen is converted into plasmin by plasminogen activators. The main plasminogen activators are tissue plasminogen activator (tPA) and pro-urokinase, which is activated into urokinase (UK) by, among others, the contact system of coagulation.

 In the bloodstream, plasmin is rapidly and specifically neutralized by alpha 2-antiplasmin, thereby restricting its fibrinogenolytic activity and localizes the fibrinolysis on the fibrin clot. On the fibrin clot, plasmin degrades fibrin into various products (ie, D-dimers). Antibodies specific for these products, which do not recognize fibrinogen, have been developed. The presence of these various fibrin degradation products, among which D-dimer is the terminal product, is the proof that the fibrinolytic system is in action in response to coagulation activation.
 
Reference Value:
0-500 ng/mL (FEU)
 
Interpretation:
Elevated D-dimer levels are found in association with disseminated intravascular coagulation (DIC), pulmonary embolism (PE), deep vein thrombosis (DVT), trauma, and bleeding. D-dimer may also be increased in association with pregnancy, liver disease, malignancy, inflammation, or a chronic hypercoagulable state.
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, D-Dimer HS. HemosiIL®, Instrumentation Laboratory Company - Bedford, MA 01730-2443 (USA) and Instrumentation Laboratory SpA - V.le Monza 338 - 20128 Milano (Italy), 02/2016
  2. https://www.mayocliniclabs.com (Retrieved: 22 Jan 2019)