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Test Code:
090-41-1501-01

Order Name:
Cryptosporidium Antigen, Stool **

 
Useful For:

Establishing the diagnosis of intestinal cryptosporidiosis.

 
Methodology:
Enzyme-Linked Immunosorbent Assay (ELISA)
 
 
 
Test Code:
090-41-1501-01

Order Name:
Cryptosporidium Antigen, Stool **

 
Patient Preparation:
N/A
 
Collection Specimen Or Container:
Stool, Sterile container


 
 
Specimen Testing Type:
Stool, minimum volume 5 g (Ship Frozen)
 
Sub Mission Container:
Sterile container
 
Rejection Criteria:


 
 
Specimen Stabillity:
Specimen Type Temperature Time
Stool  Frozen 60 days

 
 
 
 
Test Code:
090-41-1501-01

Order Name:
Cryptosporidium Antigen, Stool **

 
Method detail:
Enzyme-Linked Immunosorbent Assay (ELISA)
 
Schedule:
N/A **Sent out to MAYO, USA
 
Turnaround Time:
Received specimen to reported within 14 days
 
 
Performing Location:
MAYO Laboratory
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
090-41-1501-01

Order Name:
Cryptosporidium Antigen, Stool **

 
 
Clinical Information:

Cryptosporidia are small apicomplexan protozoan parasites that infect the intestinal tract of humans and animals. They were conventionally categorized as coccidia, but are now known to be more closely related to the gregarines. Many species may infect humans, with the most common being Cryptosporidium hominis and C parvum. Infected humans and animals shed small (4-6 micrometer in diameter) infectious oocysts in their stool, and these can subsequently contaminate and survive in recreational and drinking water supplies.
Infection of humans occurs by the fecal-oral route or via ingestion of contaminated water or food. Infection is easily acquired, with an infectious dose of approximately 100 oocysts. Waterborne transmission is a primary mode of transmission and is commonly responsible for human outbreaks. This is due to the fact that Cryptosporidium species oocysts are resistant to cold temperatures and chlorine, and require extensive filtration or water treatment to remove them from drinking water.
The incubation period is typically 7 to 10 days following exposure. While most patients have symptoms, approximately 30% of infected individuals are asymptomatic. When symptoms are present, they usually include profuse watery diarrhea, malaise, anorexia, nausea, crampy abdominal pain, and low grade fever. Infection is usually self-limited in immunocompetent individuals, with resolution of symptoms in 10 to 14 days. However, diarrhea can be prolonged and life-threatening in immunocompromised patients such as those with AIDS, infants, and the elderly, and result in severe dehydration and wasting.
The fecal ova and parasite examination is an insensitive method for detecting Cryptosporidium, given the small size of the oocysts and their lack of trichrome staining. Instead, use of the Cryptosporidium antigen test (CRYPS / Cryptosporidium Antigen, Feces) or the multiplex gastrointestinal PCR panel (GIP / Gastrointestinal Pathogen Panel, PCR, Feces) is recommended for sensitive and specific detection. The antigen test is ideal for situations in which cryptosporidiosis is highly suspected (eg outbreak scenarios), whereas the PCR panel allows for simultaneous detection of multiple parasitic, viral, and bacterial causes of diarrhea.

 
Reference Value:
Negative
 
Interpretation:

A positive enzyme-linked immunosorbent assay (ELISA) indicates the presence of antigens of cryptosporidium and is interpreted as evidence of infection with that organism.
The sensitivity, specificity, and positive predictive value of the ELISA were 87%, 99%, and 98%, respectively, as determined by examination of 231 fecal specimens by conventional microscopy and by ELISA.

 
Clinical Reference:
www.mayomedicallaboratories.com (Retrieved: 25 Jun 2020)