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Test Code:
CRU

Order Name:
Creatinine (Random Urine)

 
Useful For:
Urinary creatinine, in conjunction with serum creatinine, is used to calculate the creatinine clearance, a measure of renal function.
 
Methodology:
Enzymatic
 
AliasesName:
Creatinine, Random urine
 
 
 
Test Code:
CRU

Order Name:
Creatinine (Random Urine)

 
Collection Specimen Or Container:
Urine, Clean container 
 
Specimen Testing Type:
Urine , minimum volume 10 mL
 
Sub Mission Container:
Clean container
 
Specimen Stabillity:
Specimen Type Temperature Time
Random urine Refrigerated, 2oC to 8oC 6 days
Frozen, -20oC 6 months
 
 
 
Test Code:
CRU

Order Name:
Creatinine (Random Urine)

 
Method detail:
Enzymatic
 
Schedule:
Tested daily (24 hours)
 
Turnaround Time:
Collected specimen to report within 1.5 hours (90 mins)
 
Performing Location:
Chemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time:
7 days
 
 
 
Test Code:
CRU

Order Name:
Creatinine (Random Urine)

 
 
Clinical Information:
Creatinine is formed from the metabolism of creatine and phosphocreatine, both of which are principally found in muscle. Thus the amount of creatinine produced is in large part dependent upon the individual's muscle mass and tends not to fluctuate much from day-to-day.  

Creatinine is not protein-bound and is freely filtered by glomeruli. All of the filtered creatinine is excreted in the urine. Renal tubular secretion of creatinine also contributes to a small proportion of excreted creatinine. Although most excreted creatinine is derived from an individual's muscle, dietary protein intake, particularly of cooked meat, can contribute to urinary creatinine levels.

The renal clearance of creatinine provides an estimate of glomerular filtration rate.
 
Reference Value:
30.00 – 161.00 mg/dL
 
Interpretation:
24-Hour urinary creatinine determinations are principally used for the calculation of creatinine clearance.

Decreased creatinine clearance indicates decreased glomerular filtration rate. This can be due to conditions such as progressive renal disease, or result from adverse effect on renal hemodynamics that are often reversible including certain drugs or from decreases in effective renal perfusion (eg, volume depletion or heart failure).

Increased creatinine clearance is often referred to as "hyperfiltration" and is most commonly seen during pregnancy or in patients with diabetes mellitus, before diabetic nephropathy has occurred. It also may occur with large dietary protein intake.
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, Architect ® Creatinine (enzymatic), SENTINEL CH.SpA Via Robert Koch, 2 Milan 20152, Italy, March 2017.
  2. http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)