Test Code (รหัสการทดสอบ):
Order Name (ชื่อการทดสอบ):
Creatinine, Random Urine
Clinical Information (ข้อมูลทางคลินิก):
Creatinine is formed from the metabolism of creatine and phosphocreatine, both of which are principally found in muscle. Thus the amount of creatinine produced is in large part dependent upon the individual's muscle mass and tends not to fluctuate much from day-to-day.
Creatinine is not protein-bound and is freely filtered by glomeruli. All of the filtered creatinine is excreted in the urine. Renal tubular secretion of creatinine also contributes to a small proportion of excreted creatinine. Although most excreted creatinine is derived from an individual's muscle, dietary protein intake, particularly of cooked meat, can contribute to urinary creatinine levels.
The renal clearance of creatinine provides an estimate of glomerular filtration rate.
Reference Value (ค่าอ้างอิง):
30.00 – 161.00 mg/dL
24-Hour urinary creatinine determinations are principally used for the calculation of creatinine clearance.
Decreased creatinine clearance indicates decreased glomerular filtration rate. This can be due to conditions such as progressive renal disease, or result from adverse effect on renal hemodynamics that are often reversible including certain drugs or from decreases in effective renal perfusion (eg, volume depletion or heart failure).
Increased creatinine clearance is often referred to as "hyperfiltration" and is most commonly seen during pregnancy or in patients with diabetes mellitus, before diabetic nephropathy has occurred. It also may occur with large dietary protein intake.
Clinical Reference (เอกสารอ้างอิง):
- Manufacturer’s reagent package insert, Architect ® Creatinine (enzymatic), SENTINEL CH.SpA Via Robert Koch, 2 Milan 20152, Italy .
- http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)