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Clear
 
Test Code:
090-31-4015

Order Name:
Complement C1q, Serum **

 
Useful For:

1. Assessment of an undetectable total complement (CH50) level.
2. Diagnosing congenital C1 (first component of complement) deficiency.
3. Diagnosing acquired deficiency of C1 inhibitor.

 
Methodology:
Nephelometry
 
AliasesName:
C1Q (Complement Component C1Q), Serum
Complement Component C1q
First Component of Complement
 
 
 
Test Code:
090-31-4015

Order Name:
Complement C1q, Serum **

 
Patient Preparation:
Patient must be fasting 8-12 hours.
 
Collection Specimen Or Container:
Blood/ Plain Blood (Red Top) 5 mL, 1 tube 


 
 
Specimen Testing Type:
Serum, minimum volume 2-3 mL (Ship Frozen)
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Lipemic :4+ reject 

 
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Refrigerated (preferred) 28 days
  Frozen 28 days
  Ambient  21 days

 
 
 
 
Test Code:
090-31-4015

Order Name:
Complement C1q, Serum **

 
Method detail:
Nephelometry
 
Schedule:
N/A **Sent out to MAYO, USA
 
Turnaround Time:
Received specimen to reported within 14 days
 
 
Performing Location:
MAYO Laboratory
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
090-31-4015

Order Name:
Complement C1q, Serum **

 
 
Clinical Information:

The first component of complement (C1) is composed of 3 subunits designated as C1q, C1r, and C1s. C1q recognizes and binds to immunoglobulin complexed to antigen and initiates the complement cascade. Congenital deficiencies of any of the early complement components (C1, C2, C4) results in an inability to clear immune complexes. Inherited deficiency of C1 is rare.
Like the more common C2 deficiency, C1 deficiency is associated with increased incidence of immune complex disease (systemic lupus erythematosus, polymyositis, glomerulonephritis, and Henoch-Schonlein purpura). Low C1 levels have also been reported in patients with abnormal immunoglobulin levels (Bruton and common variable hypogammaglobulinemia and severe combined immunodeficiency). This is most likely due to increased catabolism.
The measurement of C1q is an indicator of the amount of C1 present.

 
Reference Value:
12-22 mg/dL
 
Interpretation:

An undetectable C1q in the presence of an absent total complement (CH50) and normal C2, C3, and C4 suggests a congenital C1 (first component of complement) deficiency.
A low C1q in combination with a low C1 inhibitor and low C4 suggests an acquired C1 inhibitor deficiency.

 
Clinical Reference:
www.mayomedicallaboratories.com (Retrieved: 25 Jun 2020)