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Clear
 
Test Code:
090-10-0450

Order Name:
Cold Agglutinin

 
Useful For:
Detection of cold agglutinins in patients with suspected cold agglutinin disease
 
Methodology:
Titration-Red Cell Agglutination at 4oC
 
AliasesName:
CATR
Cold Agglutinin Titer
Cryoagglutinin
 
 
 
Test Code:
090-10-0450

Order Name:
Cold Agglutinin

 
Collection Specimen Or Container:
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 3 mL
 
 
 
Test Code:
090-10-0450

Order Name:
Cold Agglutinin

 
Method detail:
Titration-Red Cell Agglutination at 4oC
 
Schedule:
Tested Daily (24 hours)
 
Turnaround Time:
Collected specimen to reported within 1 day.
 
Performing Location:
Hematology, Laboratory Department Tel. 17254
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
090-10-0450

Order Name:
Cold Agglutinin

 
 
Clinical Information:
The cold agglutinin titer test is to be used as a tool in the evaluation of suspected cold agglutinin syndrome. In this syndrome, cold agglutinins, usually IgM with anti-I specificity, attach to the patient's erythrocytes causing a variety of symptoms. Symptoms may include chronic anemia due to premature removal of the sensitized erythrocytes from circulation by hemolysis, to acrocyanosis of the ears, fingers, or toes due to local blood stasis in the skin capillaries.
 
Reference Value:
< 1:16
 
Interpretation:
Patients with cold agglutinin syndrome usually exhibit a titer value greater than 1:512, with rare cases reportedly as low as 1:64.

Normal individuals often have low levels of cold agglutinins.

The test is not a direct measure of clinical significance and must be used in conjunction with other in vitro and in vivo parameters.
 
Clinical Reference:
  1. Petz LD, Garratty G: Acquired Immune Hemolytic Anemias. New York, Churchill Livingstone, 1980
  2. Farratty G, Petz LD, Hoops JK: The correlation of cold agglutinin titrations in saline and albumin with haemolytic anaemia. Br J Haematol 1977;35:587-595
  3. http://www.mayomedicallaboratories.com (Retrieved: 22 Jan 2019)