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Overview Specimen Performance Clinical & Interpretation

Test Code:

090-21-1561-01

Order Name:

Citrate (U-24 hrs) **

Useful For:

1. Diagnosing risk factors for patients with calcium kidney stones.
2. Monitoring results of therapy in patients with calcium stones or renal tubular acidosis.

Methodology:

Enzymatic

AliasesName:

Citric Acid, Urine
Urinary Citrate Excretion

Test Code:

090-21-1561-01

Order Name:

Citrate (U-24 hrs) **

Patient Preparation:

Any drug that causes alkalemia or acidemia may be expected to alter citrate excretion and should be avoided, if possible.

Collection Specimen Or Container:

Urine 24 hours, Clean container
(Specimen must be refrigerate since collected)

Specimen Testing Type:

Urine 24 hours, minimum volume 8-10 mL + 24-Hour volume is required.

Sub Mission Container:

Clean container

Rejection Criteria:

Specimen Stabillity:

Specimen Type	Temperature	Time
Urine	Refrigerated (preferred)	14 days
	Frozen	14 days

Test Code:

090-21-1561-01

Order Name:

Citrate (U-24 hrs) **

Method detail:

Enzymatic

Schedule:

N/A **Sent out to MAYO, USA

Turnaround Time:

Received specimen to reported within 14 days

Performing Location:

MAYO Laboratory
Referral Lab Services, Laboratory Department 14160-2

Test Code:

090-21-1561-01

Order Name:

Citrate (U-24 hrs) **

Clinical Information:

Urinary citrate is a major inhibitor of kidney stone formation due in part to binding of calcium in urine. Low urine citrate levels are considered a risk for kidney stone formation. Several metabolic disorders are associated with low urine citrate. Any condition which lowers renal tubular pH or intracellular pH may decrease citrate (eg, metabolic acidosis, increased acid ingestion, hypokalemia, or hypomagnesemia).
Low urinary citrate is subject to therapy by correcting acidosis, hypokalemia, or hypomagnesemia by altering diet or using drugs such as citrate and potassium.

Reference Value:

No established reference values

Interpretation:

1. A low value represents a potential risk for kidney stone formation/growth. Patients with low urinary citrate, and new or growing stone formation may benefit from adjustments in therapy known to increase urinary citrate excretion.
2. Very low levels suggest investigation for the possible diagnosis of metabolic acidosis (eg, renal tubular acidosis).

Clinical Reference: