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Test Code:
090-31-4012

Order Name:
Cerebrospinal Fluid (CSF) IgG Index, Serum and Spinal Fluid **

 
Useful For:

Assessment of cerebrospinal fluid (CSF) IgG/albumin ratio in the absence of a paired CSF and serum specimen.

 
Methodology:
Nephelometry
 
Test List In Profile:
CSF index
CSF IgG
CSF albumin
Serum IgG
Serum albumin
CSF IgG/albumin
Serum IgG/albumin
CSF IgG synthesis rate (mg/24 hours)
 
AliasesName:
Albumin Ratio
IgG/Albumin Ratio, CSF
Specific Protein (CSF)
 
 
 
Test Code:
090-31-4012

Order Name:
Cerebrospinal Fluid (CSF) IgG Index, Serum and Spinal Fluid **

 
Collection Specimen Or Container:
1. Blood/ Plain Blood (Red Top) 5 mL, 1 tube
2. CSF/ Sterile container
 
 
Specimen Testing Type:
1. Serum, minimum volume 2-3 mL (Ship Frozen)
2. CSF, minimum volume 1 mL (Ship Frozen)
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:


 
 
Specimen Stabillity:
Specimen Type Temperature Time
CSF Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

 
 
 
 
Test Code:
090-31-4012

Order Name:
Cerebrospinal Fluid (CSF) IgG Index, Serum and Spinal Fluid **

 
Method detail:
Nephelometry
 
Schedule:
N/A **Sent out to MAYO, USA
 
Turnaround Time:
Received specimen to reported within 14 days
 
 
Performing Location:
MAYO Laboratory
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
090-31-4012

Order Name:
Cerebrospinal Fluid (CSF) IgG Index, Serum and Spinal Fluid **

 
 
Clinical Information:

Elevation of IgG levels in the cerebrospinal fluid (CSF) of patients with inflammatory diseases of the central nervous system (CNS) (multiple sclerosis: MS, neurosyphilis, acute inflammatory polyradiculoneuropathy, subacute sclerosing panencephalitis) is due to local CNS synthesis of IgG.
The 2 most commonly used diagnostic laboratory tests for MS are CSF index and oligoclonal banding. The CSF index is the CSF IgG to CSF albumin ratio compared to the serum IgG to serum albumin ratio. The CSF index is therefore an indicator of the relative amount of CSF IgG compared to serum and any increase in the index is a reflection of IgG production in the central nervous system. The IgG synthesis rate is a mathematical manipulation of the CSF index data and can also be used as a marker for CNS inflammatory diseases.

 
Reference Value:

CSF IgG: 0.0-8.1 mg/dL

CSF albumin: 0.0-27.0 mg/dL

CSF IgG/albumin: 0.00-0.21

 
Interpretation:

Cerebrospinal fluid IgG index is positive (elevated) in approximately 80% of patients with multiple sclerosis.

 
Clinical Reference:
www.mayomedicallaboratories.com (Retrieved: 24 Jun 2020)