bih.button.backtotop.text
BROWSE BY TEST NAME
%
1
2
3
5
8
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Clear
 
Test Code (รหัสการทดสอบ):
CDAA

Order Name (ชื่อการทดสอบ):
Celiac Profile

 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Turnaround Time (ระยะเวลารอผล):
Received specimen to reported within 2 days.
 
Useful For (ประโยชน์การทดสอบ):
Diagnosis of celiac disease in the suspected patient.
 
Methodology (วิธีการทดสอบ):
Enzyme-linked Immunosorbent Assay (ELISA)
 
Test List In Profile (การทดสอบใน Profile):
Deamidated Gliadin Peptide (DGP) antibody, IgA
Deamidated Gliadin Peptide (DGP) antibody, IgG
Anti-tissue Transglutaminase IgA
Anti-tissue Transglutaminase IgG
 
AliasesName (ชื่อเรียกอื่นๆ) :
Celiac Disease
Coeliac Disease
Dermatitis Herpetiformis
Gliadin Antibodies IgA
Gliadin Antibodies IgG
Gliadin IgA, Serum
Gliadin IgG, Serum
Gluten-sensitive Enteropathy
Sprue
Tissue Transglutaminase (tTG)
Tissue Transglutaminase Ab IgA
Transglutaminase (tTG)
Deamidated Gliadin Peptide (DGP) antibody
 
 
 
Test Code (รหัสการทดสอบ):
CDAA

Order Name (ชื่อการทดสอบ):
Celiac Profile

 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Serum, minimum volume 0.5 mL
 
Sub Mission Container (ภาชนะส่งตรวจ):
Plastic tube
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):
Hemolysis: Mild OK; Gross reject
Lipemia: Mild OK; Gross reject
Icterus: Mild OK; Gross reject
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
Specimen Type Temperature Time
Serum Refrigerated, 2oC to 8oC 14 days
 
 
 
Test Code (รหัสการทดสอบ):
CDAA

Order Name (ชื่อการทดสอบ):
Celiac Profile

 
Method detail (วิธีการทดสอบ):
Enzyme-linked Immunosorbent Assay (ELISA)
 
Schedule (ตารางการทดสอบ):
Test daily, at 01:00 p.m.
 
Turnaround Time (ระยะเวลารอผล):
Received specimen to reported within 2 days.
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Molecular biology & Genetics, Laboratory Department Tel.14168
 
Specimen Retention Time (ระยะเวลาเก็บสิ่งส่งตรวจ):
7 days
 
 
 
Test Code (รหัสการทดสอบ):
CDAA

Order Name (ชื่อการทดสอบ):
Celiac Profile

 
 
Clinical Information (ข้อมูลทางคลินิก):
The highly sensitive tests Anti-Gliadin (GAF-3X) ELISA serve for the determination of the celiac disease related fraction of gliadin antibodies in the serological diagnosis of gluten-sensitive enteropathy (celiac disease, non-tropical sprue) and Duhring’s dermatitis herpetiformis. Celiac disease is an autoimmune disease which occurs in predisposed individuals as a reaction to gluten sensitivity. After absorption in the lamina propria of the intestinal mucosa gliadin is deamidated by tissue transglutaminase (tTG). In this process particular glutamine residues are replaced by glutamic acid residues. In individuals with a genetic predisposition pieces (peptides) of gliadin modified (reconstructed) in this way bind to e.g. HLADQ2/8 molecules of the antigen presenting cells and are presented to helper T cells. An extensive immune reaction is triggered, causing pathological tissue changes, particularly damage to the small intestine. Components of this immune reaction are antibodies against endomysium or tTG and against the deamidated gliadin generated by tTG. The frequency of diagnosed coeliac disease amounts to around 1:300 in western Ireland, Italy, the USA, the Middle East, India and Cuba, around 1:1,000 in Germany and Austria and around 1:2,000 to 1:4,500 in other European countries. The clinical symptoms comprise fatigue (78%), borborygmus (72%), abdominal pain (64%), diarrhoea (56%), effects of malabsorption (44%) with weight loss, anaemia and growth retardation in children, vomiting (16%), constipation (12%) and bone pains (12%). Some patients with glutensensitive enteropathy also suffer from Duhring's dermatitis herpetiformis (10%), a chronic skin disease accompanied by the formation of blisters. In a prolonged course, mainly in adults, the risk of melanoma, particularly intestinal T-cell lymphoma, is about 10%
 
Reference Value (ค่าอ้างอิง):
Test Reference Value Unit
Deamidated Gliadin Peptide (DGP) antibody, IgA <25 RU/mL
Deamidated Gliadin Peptide (DGP) antibody, IgG <25 RU/mL
Anti-tissue Transglutaminase IgA <20 RU/mL
Anti-tissue Transglutaminase IgG Negative -
 
Interpretation (การแปลผล):
See details from individual unit test.
 
Clinical Reference (เอกสารอ้างอิง):
See details from individual unit test.