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Clear
 
Test Code:
AMM

Order Name:
Ammonia

 
Useful For:
  • Assisting in the diagnosis of hepatic coma                    
  • Investigating and monitoring treatment for inborn errors of metabolism
  • Evaluating patients with advanced liver disease
 
Methodology:
Glutamate Dehydrogenase
 
AliasesName:
NH3
 
 
 
Test Code:
AMM

Order Name:
Ammonia

 
Patient Preparation:
Should  not  smoke before blood collection.
 
Collection Specimen Or Container:
Blood/ K3 EDTA (Lavender Top) 3 mL, 1 tube
 
Specimen Testing Type:
EDTA plasma, minimum volume 3 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: Mild reject.
Lipemia: 2+ reject.
Icterus: 4+ reject.
Other: Specimen that over 15 minutes after collected will be reject.
 
Specimen Stabillity:
EDTA Plasma  - within 15 minutes after blood collection.
 
 
 
Test Code:
AMM

Order Name:
Ammonia

 
Method detail:
Glutamate Dehydrogenase
 
Schedule:
Tested Daily (24 hours).
 
Turnaround Time:
Specimen collected to reported within 1:30 Hours (90 Mins).
 
Performing Location:
Chemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
AMM

Order Name:
Ammonia

 
 
Clinical Information:
Ammonia, derived from the catabolism of amino acids and from the action of intestinal bacteria on dietary protein, is converted to urea in the liver hepatocytes and so rendered non-toxic. Studies have shown that excess ammonia can have a toxic effect on the central nervous system and clinical manifestations are typically neurological disturbances.
Elevated ammonia may also be observed in severe liver failure, as may occur in Reye’s Syndrome, viral hepatitis, or cirrhosis. Hyperammonemia occurs with genetic defects of the urea cycle and some other hereditary disorders. Therefore, elevated plasma ammonia may occur in the pediatric population. Elevated ammonia has also been reported due to administration of valproic acid.
 
Reference Value:
18 – 72 µmol/L
 
Interpretation:
Plasma ammonia concentrations do not correlate well with the degree of hepatic encephalopathy.
Elevated ammonia concentration may also be found with increased dietary protein intake.
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, Architect® Ammonia Ultra, SENTINEL CH.SpA, Via Robert Koch, 2 Milan 20152, Italy, July 2017.
  2. www.mayomedicallaboratories.com (Retrieved: 1 Jan 2019)