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Clear
 
Test Code:
090-21-1630

Order Name:
Alkaline Phosphatase, Total and Isoenzymes

 
Useful For:
Diagnosis and treatment of liver, bone, intestinal, and parathyroid diseases.
Determining the tissue source of increased alkaline phosphatase (ALP) activity in serum.
Differentiating between liver and bone sources of elevated ALP.
 
Methodology:
ALP: Photometric, p-Nitrophenol Phosphate
ALKE: Electrophoresis
 
Test List In Profile:
ALP (Alkaline Phosphatase)
ALKE (Alkaline Phosphatase Isoenzymes)
 
AliasesName:
ALKI
Alkaline Phosphatase, Total and Isoenzymes, Serum
 
 
 
Test Code:
090-21-1630

Order Name:
Alkaline Phosphatase, Total and Isoenzymes

 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 2 tubes
 
Specimen Testing Type:
Serum, minimum volume 1-2 mL (2 tubes)
 
Sub Mission Container:
Plastic tubes (2 tubes)
 
Rejection Criteria:
Hemolysis: Mild reject; Gross reject
Lipemia: Mild OK; Gross OK
Icterus: Mild OK; Gross OK
Other: N/A
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Ambient 7 days
Serum Refrigerated, 2oC to 8oC 7 days
Serum Frozen (preferred) 14 days
 
 
 
Test Code:
090-21-1630

Order Name:
Alkaline Phosphatase, Total and Isoenzymes

 
Method detail:
ALP: Photometric, p-Nitrophenol Phosphate
ALKE: Electrophoresis
 
Schedule:
N/A **Sent out to MAYO, USA
 
Turnaround Time:
Received specimen to report within14 days
 
Performing Location:
MAYO Laboratory
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
090-21-1630

Order Name:
Alkaline Phosphatase, Total and Isoenzymes

 
 
Clinical Information:
Alkaline phosphatase (ALP) is present in a number of tissues including liver, bone, intestine, and placenta. The activity of ALP found in serum is a composite of isoenzymes from those sites and, in some circumstances, placental or Regan isoenzymes. Serum ALP is of interest in the diagnosis of 2 main groups of conditions-hepatobiliary disease and bone disease associated with increased osteoblastic activity.
 
Reference Value:
 
Alkaline Phosphatase
Sex Age Reference Value Unit
Male 0 - 14 days 83 - 248 U/L
15 days - <1 year 122 - 469 U/L
1 year - <10 years 142 - 335 U/L
10 years - <13 years 129 - 417 U/L
13 years - <15 years 116 - 468 U/L
15 years - <17 years 82 - 331 U/L
17 years - <19 years 55 - 149 U/L
19 years or above 40 - 129 U/L
Female 0 - 14 days 83 - 248 U/L
15 days - <1 year 122 - 469 U/L
1 year - <10 years 142 - 335 U/L
10 years - <13 years  129 - 417 U/L
13 years - <15 years 57 - 254 U/L
15 years - <17 years 50 - 117 U/L
17 year or above 35 - 104 U/L


 

Alkaline Phosphatase Isoenzymes
Age Reference Value
(Liver 1%)
Unit Reference Value
(Liver 1)
Unit
0 year - 6 years 5.1 - 49.0 % 7.0 - 112.7 IU/L
7 years - 9 years 3.0 - 45.0 % 7.4 - 109.1 IU/L
10 years - 13 years 2.9 - 46.3 % 7.8 - 87.6 IU/L
14 years - 15 years 7.8 - 48.9 % 10.3 - 75.6 IU/L
16 years - 18 years 14.9 - 50.5 % 13.7 - 78.5 IU/L
19 years or above 27.8 - 76.3 % 16.2 - 70.2 IU/L
 
Age Reference Value
(Liver 2%)
Unit Reference Value
(Liver 2)
Unit
0 year - 6 years 2.9 - 13.7 % 3.0 - 41.5 IU/L
7 years - 9 years 3.7 - 12.5 % 4.0 - 35.6 IU/L
10 years - 13 years 2.9 - 22.3 % 3.3 - 37.8 IU/L
14 years - 15 years 2.2 - 19.8 % 2.2 - 32.1 IU/L
16 years - 18 years 1.9 - 12.5 % 1.4 - 19.7 IU/L
19 years or above 0.0 - 8.0 % 0.0 - 5.8 IU/L
 
Age Reference Value
(Bone %)
Unit Reference Value
(Bone)
Unit
0 year - 6 years 41.5 - 82.7 % 43.5 - 208.1 IU/L
7 years - 9 years 39.9 - 85.8 % 41.0 - 258.3 IU/L
10 years - 13 years 31.8 - 91.1 % 39.4 - 346.1 IU/L
14 years - 15 years 30.6 - 85.4 % 36.4 - 320.5 IU/L
16 years - 18 years 38.9 - 72.6 % 32.7 - 214.6 IU/L
19 years or above 19.1 - 67.7 % 12.1 - 42.7 IU/L
 
Age Reference Value
(Intestine %)
Unit Reference Value
(Intestine)
Unit
0 year - 6 years 0.0 - 18.4 % 0.0 - 37.7 IU/L
7 years - 9 years 0.0 - 18.3 % 0.0 - 45.6 IU/L
10 years - 13 years 0.0 - 11.8 % 0.0 - 40.0 IU/L
14 years - 15 years 0.0 - 8.2 % 0.0 - 26.4 IU/L
16 years - 18 years 0.0 - 8.7 % 0.0 - 12.7 IU/L
19 years or above 0.0 - 20.6 % 0.0 - 11.0 IU/L
 
Placental: Not present
 
Interpretation:
A rise in ALP activity occurs with all forms of cholestasis, particularly with obstructive jaundice. The response of the liver to any form of biliary tree obstruction is to synthesize more ALP. The main site of new enzyme synthesis is the hepatocytes adjacent to the biliary canaliculi.

ALP also is elevated in disorders of the skeletal system that involve osteoblast hyperactivity and bone remodeling, such as Paget's disease rickets and osteomalacia, fractures, and malignant tumors.

Moderate elevation of ALP may be seen in other disorders such as Hodgkin's disease, congestive heart failure, ulcerative colitis, regional enteritis, and intra-abdominal bacterial infections.
 
Clinical Reference:
www.mayomedicallaboratories.com (Retrieved: 24 Jan 2019)