APOE for Cardio report (WES/WGS add-on panel)

Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):

Specimen: Not required

Document required:
For BH: Consent for Genetic Testing (PGM-00101)
For B2B: Consent for Genomic Medicine Testing, Please click LINK

Turnaround Time (ระยะเวลารอผล):

Report within 2 weeks

Useful For (ประโยชน์การทดสอบ):

Healthy people who are interested to know about the risk of APOE gene for developing Cardiovascular Disease.

Methodology (วิธีการทดสอบ):

Data analysis using Whole Exome Sequencing (WES) data

Test List In Profile (การทดสอบใน Profile):

1. APOE Cardio report (WES add-on panel)

AliasesName (ชื่อเรียกอื่นๆ) :

Whole exome sequencing, WES, APOE, Cardio

Test Code (รหัสการทดสอบ):

092-10-0085

Order Name (ชื่อการทดสอบ):

APOE for Cardio report (WES/WGS add-on panel)

Patient Preparation (การเตรียมตัวผู้ป่วย):

This test can only be requested for patients who have previously undergone Whole Exome Sequencing (WES) at Bumrungrad Hospital.

Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):

Specimen: Not required

Document required:
For BH: Consent for Genetic Testing (PGM-00101)
For B2B: Consent for Genomic Medicine Testing, Please click LINK

Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):

Not required

Sub Mission Container (ภาชนะส่งตรวจ):

N/A

Test Code (รหัสการทดสอบ):

092-10-0085

Order Name (ชื่อการทดสอบ):

APOE for Cardio report (WES/WGS add-on panel)

Turnaround Time (ระยะเวลารอผล):

Report within 2 weeks

Performing Location (หน่วยงานที่ทำการทดสอบ):

Laboratory – Clinical Genomics Tel 14252, 14596

Test Code (รหัสการทดสอบ):

092-10-0085

Order Name (ชื่อการทดสอบ):

APOE for Cardio report (WES/WGS add-on panel)

Clinical Information (ข้อมูลทางคลินิก):

Apolipoprotein E (APOE) is a major component of lipoproteins and plays an important role in lipid transport and metabolism, influencing plasma LDL‑cholesterol and overall cardiovascular risk. The common APOE alleles (ε2, ε3, ε4) show allele‑dependent effects on lipid profiles: ε4 is generally associated with higher LDL‑cholesterol and an increased risk of ischemic heart disease and stroke, ε3 is considered neutral, and ε2 is often protective for coronary artery disease but may predispose to dyslipidemia in some contexts. APOE genotyping can therefore provide additional risk‑stratification information in patients with hypercholesterolemia, premature atherosclerotic cardiovascular disease, or complex lipid disorders, and may help to individualize lipid‑lowering and preventive strategies when interpreted alongside standard clinical and biochemical data.

Clinical Reference (เอกสารอ้างอิง):

1. Eichner JE, Dunn ST, Perveen G, Thompson DM, Stewart KE, Stroehla BC. Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review. Am J Epidemiol. 2002 Mar 15155(6):487-95.
2. Schaefer EJ, Lamon-Fava S, Johnson S, Ordovas JM, Schaefer MM, Castelli WP, Wilson PW. Effects of gender and menopausal status on the association of apolipoprotein E phenotype with plasma lipoprotein levels. Results from the Framingham Offspring Study. Arterioscler Thromb. 1994 Jul14(7):1105-13.
3. Song Y, Stampfer MJ, Liu S. Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease. Ann Intern Med. 2004 Jul 20141(2):137-47.