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Test Code:
ALT

Order Name:
ALT/ SGPT (Alanine Aminotransferase)

 
Useful For:
Diagnosis and monitoring of liver disease associated with hepatic necrosis
 
Methodology:
NADH (without P-S'-P)
 
AliasesName:
ALT
SGPT
Alanine Aminotransferase
 
 
 
Test Code:
ALT

Order Name:
ALT/ SGPT (Alanine Aminotransferase)

 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 0.5 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis:4+ reject
 
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Refrigerated, 2oC to 8oC 7 days
Frozen, less than -40oC 2 months
 
 
 
Test Code:
ALT

Order Name:
ALT/ SGPT (Alanine Aminotransferase)

 
Method detail:
NADH (without P-S'-P)
 
Schedule:
Tested daily (24 hours)
 
Turnaround Time:
Collected specimen to report within 1.5 hours (90 mins)
 
Performing Location:
Chemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
ALT

Order Name:
ALT/ SGPT (Alanine Aminotransferase)

 
 
Clinical Information:
Alanine Aminotransferase (ALT), also referred to as glutamate pyruvate transaminase (GPT), is an enzyme involved in amino acid metabolism. It is found in many tissues, but the highest levels are found in liver and kidney tissues. Tissue destruction leads to the release of the intracellular enzyme into the circulating blood. Markedly elevated serum ALT levels may be found in a variety of diseases which involve the liver, such as hepatitis, mononucleosis, and cirrhosis. These very high levels of ALT are not usually observed in other disease processes, e.g., myocardial infarction; thus, ALT is regarded as a reasonably specific indicator of liver disease.
 
Reference Value:
0 – 45 U/L
 
Interpretation:
Elevated alanine aminotransferase (ALT) values are seen in parenchymal liver diseases characterized by a destruction of hepatocytes. Values are typically at least 10 times above the normal range. Levels may reach values as high as 100 times the upper reference limit, although 20- to 50-fold elevations are most frequently encountered. In infectious hepatitis and other inflammatory conditions affecting the liver, ALT is characteristically as high as or higher than aspartate aminotransferase (AST), and the ALT:AST ratio, which normally and in other condition is less than 1, becomes greater than unity. ALT levels are usually elevated before clinical signs and symptoms of disease appear.
 
Clinical Reference:
  1. Manufacturer’s reagent package insert, Architect® Triglyceride, Abbott Laboratories, Abbott Park IL 60064 USA, December 2012.
  2. http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)