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Test Code:
ACTH

Order Name:
ACTH (Adrenocorticotrophic Hormone) **

 
Useful For:
Determining the cause of hypercortisolism and hypocortisolism.
Help to evaluate adrenal insufficiency and hypersecretion such as Addison's disease, Cushing's syndrome patient with cortisol hypersecretion.
 
Methodology:
Chemiluminescent immunoassay (CLIA)
 
AliasesName:
ACTH (Adrenocorticotropic Hormone)
ACTH (Corticotropin)
Adrenal Corticotropin Hormone
Corticotropin
Cushing's Disease
Cortrosyn
 
 
 
Test Code:
ACTH

Order Name:
ACTH (Adrenocorticotrophic Hormone) **

 
Patient Preparation:
For the 12 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.
 
Collection Specimen Or Container:
Blood/ EDTA (Lavender top) 3 mL, 2 tubes

Sent to Laboratory within 15 minutes after collect
 
Specimen Testing Type:
EDTA plasma, minimum volume 3-5 mL (Ship Frozen)
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Hemolysis - Reject

 
 
Specimen Stabillity:
Specimen Type Temperature Time
Plasma EDTA Refrigerated, 2oC to 8o 3 hrs.
Plasma EDTA Frozen (preferred) 28 days

 
 
 
 
Test Code:
ACTH

Order Name:
ACTH (Adrenocorticotrophic Hormone) **

 
Method detail:
Chemiluminescent immunoassay (CLIA)
 
Schedule:
N/A **Sent Out to Chulalongkorn
 
Turnaround Time:
Received specimen to reported within 1-2 days
(exception for official holidays)
 
Performing Location:
CMDL, Chulalongkorn
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
ACTH

Order Name:
ACTH (Adrenocorticotrophic Hormone) **

 
 
Clinical Information:
Adrenocorticotropic hormone (ACTH) is synthesized by the pituitary in response to corticotropin-releasing hormone (CRH), which is released by the hypothalamus. ACTH stimulates adrenal cortisol production. Plasma ACTH and cortisol levels exhibit peaks (6-8 a.m.) and troughs (11 p.m.).
 
Reference Value:
0-46 pg/mL
 
Interpretation:

In a patient with hypocortisolism, an elevated adrenocorticotropic hormone (ACTH) indicates primary adrenal insufficiency, whereas a value that is not elevated is consistent with secondary adrenal insufficiency from a pituitary or hypothalamic cause.

In a patient with hypercortisolism (Cushing syndrome), a suppressed value is consistent with a cortisol-producing adrenal adenoma or carcinoma, primary adrenal micronodular hyperplasia, or exogenous corticosteroid use.

Normal or elevated ACTH in a patient with Cushing syndrome puts the patient in the ACTH-dependent Cushing syndrome category. This is due to either an ACTH-producing pituitary adenoma or ectopic production of ACTH (bronchial carcinoid, small cell lung cancer, others). Further diagnostic studies such as dexamethasone suppression testing, corticotropin-releasing hormone stimulation testing, petrosal sinus sampling, and imaging studies are usually necessary to define the ACTH source.

ACTH concentrations vary considerably depending on physiological conditions. Therefore, ACTH results should always be evaluated with simultaneously measured cortisol concentrations.

 
Clinical Reference:
  1. https://cmdl.md.chula.ac.th (Retrieved: 27 May 2020) 
  2. www.mayomedicallaboratories.com (Retrieved: 27 May 2020)