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Test Code:
ACE

Order Name:
ACE (Angiotensin Converting Enzyme), Blood **

 
Useful For:
Evaluation of patients with suspected sarcoidosis
 
Methodology:
Spectrophotometry (SP)
 
AliasesName:
ACE (Angiotensin Converting Enzyme) Angiotensin-1-Converting Enzyme Kinase II Peptidylpeptide Hydrolase SACE (Serum Angiotensin Convert
Angiotensin-1-Converting Enzyme
Kinase II
Peptidylpeptide Hydrolase
SACE (Serum Angiotensin Converting Enzyme)
Sarcoidosis
Serum Angiotensin Converting Enzyme
ACE (Angiotensin Converting Enzyme)
 
 
 
Test Code:
ACE

Order Name:
ACE (Angiotensin Converting Enzyme), Blood **

 
Collection Specimen Or Container:
Blood/ Plain blood (Red top) 6 mL, 2 tubes
 
Specimen Testing Type:
Serum, minimum volume 2 mL
 
Sub Mission Container:
Plastic tube
 
Rejection Criteria:
Hemolysis: Mild reject; Gross reject
Lipemia: Mild OK; Gross reject
Icterus: Mild reject; Gross reject
Other: N/A
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum Ambient 24 hours
Serum Refrigerated, 2oC to 8oC (preferred) 7 days
Serum Frozen 180 days
 
 
 
Test Code:
ACE

Order Name:
ACE (Angiotensin Converting Enzyme), Blood **

 
Method detail:
Spectrophotometry (SP)
 
Schedule:
N/A **Sent out to MAYO, USA
 
Turnaround Time:
Received specimen to report within 14 days
 
Performing Location:
MAYO Laboratory
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code:
ACE

Order Name:
ACE (Angiotensin Converting Enzyme), Blood **

 
 
Clinical Information:
Angiotensin converting enzyme (ACE) participates in the renin cascade in response to hypovolemia. Its peptidase action on the decapeptide angiotensinogen I results in the hydrolysis of a terminal histidyl leucine dipeptide and the formation of the octapeptide angiotensin II, a potent vasoconstrictor that increases blood pressure.
 
Reference Value:

> or =18 years: 16-85 U/L

0-17 years: ACE activity may be 20-50% higher in healthy children compared to healthy adults (16-85 U/L).

Necessary Information
The use of angiotensin converting enzyme (ACE)-inhibiting antihypertensive drugs will cause decreased ACE values. Patients taking ACE inhibitors, such as captopril and enalapril, will have extremely low or unmeasurable ACE activity. 

 

 
Interpretation:
An elevation in the level of serum angiotensin converting enzyme (ACE), along with radiographic evidence of infiltrates or adenopathy and organ biopsies showing noncaseating epithelial granulomas is suggestive of a diagnosis of sarcoidosis.

Serum ACE is significantly higher in most (approximately 80%) patients with active sarcoidosis. ACE is also elevated in a number of other diseases and in approximately 5% of the normal adult population.
 
Clinical Reference:
www.mayomedicallaboratories.com (Retrieved: 24 Jan 2019)