bih.button.backtotop.text
BROWSE BY TEST NAME
%
1
2
3
5
8
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Clear
 
Test Code (รหัสการทดสอบ):
090-31-4026

Order Name (ชื่อการทดสอบ):
21-Hydroxylase Antibodies, Serum **

 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain blood (Red top) 6 mL, 2 tubes
 
Turnaround Time (ระยะเวลารอผล):
Receive specimen to report within 14-21 days
 
Useful For (ประโยชน์การทดสอบ):
  • Investigation of adrenal insufficiency
  • Aid in the detection of those at risk of developing autoimmune adrenal failure in the future
HIGHLIGHTS
Addison disease is the most frequent cause of primary adrenal insufficiency.
Auto-antibodies against 21-hydroxylase are present in up to 90% of Addison disease cases.
Measurement of anti-21-hydroxylase auto-antibodies is useful in the evaluation of the cause of established primary adrenal insufficiency.
 
Methodology (วิธีการทดสอบ):
Enzyme-linked Immunosorbent Assay (ELISA)
 
AliasesName (ชื่อเรียกอื่นๆ) :
21OH
21 Hydroxylase Antibody
21-OH Ab
Adrenal Antibody
Anti-Adrenal Antibody
Hydroxylase Antibody
Addison's Disease
21-Hydroxylase Ab, S
 
 
 
Test Code (รหัสการทดสอบ):
090-31-4026

Order Name (ชื่อการทดสอบ):
21-Hydroxylase Antibodies, Serum **

 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain blood (Red top) 6 mL, 2 tubes
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Serum, minimum volume 2 mL x 2 tubes
 
Sub Mission Container (ภาชนะส่งตรวจ):
Plastic tube
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):
Hemolysis: Gross reject
Lipemia: Gross reject
Icterus: Gross OK
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
Specimen Type Temperature Time
Serum Frozen 14 days
 
 
 
Test Code (รหัสการทดสอบ):
090-31-4026

Order Name (ชื่อการทดสอบ):
21-Hydroxylase Antibodies, Serum **

 
Method detail (วิธีการทดสอบ):
Enzyme-linked Immunosorbent Assay (ELISA)
 
Schedule (ตารางการทดสอบ):
N/A **Sent out to MAYO, USA
 
Turnaround Time (ระยะเวลารอผล):
Receive specimen to report within 14-21 days
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
MAYO Laboratory
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code (รหัสการทดสอบ):
090-31-4026

Order Name (ชื่อการทดสอบ):
21-Hydroxylase Antibodies, Serum **

 
 
Clinical Information (ข้อมูลทางคลินิก):
Adrenal insufficiency is caused by failure of the adrenal cortex to produce cortisol. This failure can result from loss of function of the adrenal glands (ie, primary adrenal insufficiency). This is most frequently caused by autoimmune adrenalitis or Addison disease accounting for 68% to 94% of cases. It can occur sporadically or in combination with other autoimmune endocrine diseases that together comprise Type I or Type II autoimmune polyglandular syndrome (APS).
 
Antibodies that react with several steroidogenic enzymes (most often 21-hydroxylase) are present in the serum of up to 86% of patients with autoimmune primary adrenal insufficiency, but only rarely in patients with other causes of adrenal insufficiency. Therefore, anti-21-hydroxylase autoantibodies (21-OH Abs) are markers of autoimmune Addison disease, whether it’s present alone, or as part of Type I or Type II APS. The measurement of 21-OH Abs is an important step in the investigation of adrenal insufficiency, and may also aid in the detection of those at risk of developing autoimmune adrenal failure in the future.
 
Reference Value (ค่าอ้างอิง):

Negative

 
Interpretation (การแปลผล):
This is a qualitative test. A positive result indicates the presence of autoantibodies to 21-hydroxylase and is consistent with Addison disease.
 
Utilizing an index value of <45 as a negative cutoff, this assay has a clinical sensitivity and specificity of 87.0% (95% CI: 79.4%-92.2%) and 99.3% (95% CI: 97.5%-99.8%), respectively.

CAUTIONS 
  • Lipemic or grossly hemolyzed serum should not be used in this assay.
  • Results should be interpreted in the context of clinical symptoms and adrenal functional confirmatory tests.
 
Clinical Reference (เอกสารอ้างอิง):
www.mayomedicallaboratories.com (Retrieved: 09 Mar 2022)