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Clear
 
Test Code:
090-30-1420-01

Order Name:
Vancomycin* (blood)

 
Useful For:
Used in the diagnosis and treatment of vancomycin overdose and in monitoring levels of vancomycin to help ensure appropriate therapy.
 
Methodology:
Particle-enhanced turbidimetric inhibition immunoassay (PETINIA)
 
 
 
Test Code:
090-30-1420-01

Order Name:
Vancomycin* (blood)

 
Patient Preparation:
Follow by Physician or Pharmacist recommedation.
 
Collection Specimen Or Container:
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type:
Serum, minimum volume 0.5 mL
 
Sub Mission Container:
Plastic vial
 
Rejection Criteria:
Hemolysis: 4+ reject
 
Specimen Stabillity:
Specimen Type Temperature Time
Serum (keep in original tube) Room Temperature 8 hours
Serum Refrigerated, 2oC to 8oC 7 days
Frozen, -10oC 14 days
 
 
 
Test Code:
090-30-1420-01

Order Name:
Vancomycin* (blood)

 
Method detail:
Particle-enhanced turbidimetric inhibition immunoassay (PETINIA)
 
Schedule:
Tested daily (24 hours)
 
 
Turnaround Time:
Specimen collected to reported within 1:30 Hours (90 Mins)
 
Performing Location:
Biochemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time:
5 days
 
 
 
Test Code:
090-30-1420-01

Order Name:
Vancomycin* (blood)

 
 
Clinical Information:
Vancomycin hydrochloride is a tricyclic glycopeptide derived from Amycolatopsis orientalis. It is commonly used in the treatment of methicillin-resistant Staphylococcus aureus infections. This glycopeptide inhibits the growth of the bacterium by intervening in the cell wall synthesis, thereby killing the bacterium. Extensive review articles have been published which fully examine vancomycin’s effectiveness and pharmacokinetics.
Vancomycin is absorbed minimally from the gastrointestinal tract. In the first 24 hours after intravenous dosing, the usual route of administration, about 90% of the vancomycin is excreted unchanged by the kidneys. The average half-life in patients with normal renal function is about 6 hours. Vancomycin is approximately 55% bound to plasma proteins. Therapeutic serum levels vary depending on the microorganism involved and the patient’s tolerance to the drug. Vancomycin serum or plasma concentrations are monitored to guide therapy, since individual patient differences require dose changes that are difficult to predict. Monitoring serum or plasma levels of vancomycin decreases the frequency of serious toxic effects.
 
Reference Value:
Therapeutic range = 20 - 40 ug/mL (Peak Level)
Therapeutic range = 10 - 20 ug/mL (Trough Level)
 
Clinical Reference:
1. Manufacturer’s reagent package insert, Architect® Vancomycin, ABBOTT, Microgenics Corporation 46500 Kato Road, Fremont CA, 94538, USA, October 2016.
2. Reference range: Vancomycin: Parenteral dosing, monitoring, and adverse effects in adults, Authors : Richard H Drew, PharmD, MS, FCCP, FIDPGeorge Sakoulas, MD. , https://www.uptodate.com/contents/vancomycin-parenteral-dosing-monitoring-and-adverse-effectsin-adults. (Retrieved: July2018)