Uric acid is a metabolite of purines, nucleic acids, and nucleoproteins. Consequently, abnormal levels may be indicative of a disorder in the metabolism of these substances. Hyperuricemia may be observed in renal dysfunction, gout, leukemia, polycythemia, atherosclerosis, diabetes, hypothyroidism, or in some genetic diseases. Decreased levels are present in patients with Wilson’s disease.
Urinary uric acid excretion is elevated in a significant proportion of patients with uric acid stones.
Uric acid excretion can be either decreased or increased in response to a variety of pharmacologic agents.
Urine uric acid levels are elevated in states of uric acid overproduction such as in leukemia and polycythemia and after intake of food rich in nucleoproteins.